Division of Endocrinology, S. Orsola-Malpighi Hospital, University Alma Mater Studiorum, via Massarenti 9, 40138 Bologna, Italy.
Eur J Obstet Gynecol Reprod Biol. 2010 Mar;149(1):31-6. doi: 10.1016/j.ejogrb.2009.11.010. Epub 2010 Jan 6.
To determine whether maternal polycystic ovary syndrome (PCOS) is associated with adverse pregnancy outcomes in a population of Italian parturients.
Retrospective study carried out in an academic hospital in Bologna, Italy, including 516 consecutive Italian women who delivered between January and April 2006. PCOS women, women with hyperandrogenic features not configuring PCOS (Intermediate group) and non-hyperandrogenic controls were identified by a telephone survey of 229 women. Statistical analysis was performed using ANOVA or chi-square.
PCOS women, accounted for 6.6% of our cohort. Gestational diabetes mellitus (GDM) was significantly more frequent in the PCOS group than in the other groups (20% vs. 3.6% and 4%; P<0.01). The association of GDM and pregnancy-induced hypertension occurred in one subject in the PCOS group but in none of the other groups (P<0.001). Preterm birth was more frequent in the PCOS group than in control group (20% vs. 6.9%; P<0.05), whereas mean length of gestation was not different. The higher occurrence of adverse outcomes may be, at least partly, related to a higher weight gain during pregnancy in PCOS group with respect to the other groups (P<0.05).
Women affected by PCOS carry an increased risk of adverse pregnancy outcomes.
在意大利产妇人群中，确定母体多囊卵巢综合征（PCOS）是否与不良妊娠结局相关。
这是在意大利博洛尼亚的一家学术医院进行的回顾性研究，纳入了 2006 年 1 月至 4 月期间连续分娩的 516 名意大利女性。通过对 229 名女性进行电话调查，确定了患有 PCOS 的女性、具有雄激素过多特征但不符合 PCOS 标准的女性（中间组）和非雄激素过多的对照组。采用方差分析或卡方检验进行统计学分析。
PCOS 女性占我们队列的 6.6%。与其他组相比，PCOS 组的妊娠期糖尿病（GDM）发生率显著更高（20%比 3.6%和 4%；P<0.01）。GDM 和妊娠高血压的关联仅在 PCOS 组的 1 例患者中发生，而在其他组中均未发生（P<0.001）。与对照组相比，PCOS 组早产的发生率更高（20%比 6.9%；P<0.05），而平均孕龄无差异。不良结局的更高发生率可能至少部分与 PCOS 组在妊娠期间体重增加多于其他组有关（P<0.05）。
患有 PCOS 的女性发生不良妊娠结局的风险增加。
