Drulis-Kawa Zuzanna, Bednarkiewicz Artur, Bugla-Płoskonska Gabriela, Strek Wiesław, Doroszkiewicz Włodzimierz
Institute of Genetics and Microbiology, University of Wrocław, Poland.
Pol J Microbiol. 2005;54(4):305-10.
Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report the activity of the Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against anaerobic bacteria isolated from periodontal diseases. Over 99.9% reduction in colony forming units in 20 Gram-positive and 30 Gram-negative clinical anaerobic strains was obtained.
光动力灭活（PDI）可能是一种非常有前景的治疗牙周炎的抗菌替代方法。多项研究已证明使用甲苯胺蓝、亚甲蓝和氯e6衍生物时龈下菌群对PDI敏感。在本研究中，我们报告了由氯e6和聚乙烯吡咯烷酮（PVP）组成的Fotolon敏化剂对从牙周疾病中分离出的厌氧菌的活性。在20株革兰氏阳性和30株革兰氏阴性临床厌氧菌株中，菌落形成单位减少了99.9%以上。
