Rukayadi Y, Hwang J-K
Department of Biotechnology and Bioproducts Research Center, Yonsei University, Seoul, South Korea.
Lett Appl Microbiol. 2006 Apr;42(4):400-4. doi: 10.1111/j.1472-765X.2006.01876.x.
We determined the effect of xanthorrhizol (XTZ) purified from the rhizome of Curcuma xanthorrhiza Roxb. on the Streptococcus mutans biofilms in vitro.
The biofilms of S. mutans at different phases of growth were exposed to XTZ at different concentrations (5, 10 and 50 micromol l(-1)) and for different time exposures (1, 10, 30 and 60 min). The results demonstrated that the activity of XTZ in removing S. mutans biofilm was dependent on the concentration, exposure time and the phase growth of biofilm. A concentration of 5 micromol l(-1) of XTZ completely inhibited biofilm formation by S. mutans at adherent phases of growth, whereas 50 micromol l(-1) of XTZ removed 76% of biofilm at plateau accumulated phase when exposed to S. mutans biofilm for 60 min.
Xanthorrhizol isolated from an edible plant (C. xanthorrhiza Roxb.) shows promise as an antibacterial agent for inhibiting and removing S. mutans biofilms in vitro.
XTZ could be used as a potential antibacterial agent against biofilm formation by S. mutans.
我们测定了从郁金根茎中纯化得到的莪术二酮（XTZ）对变形链球菌生物膜的体外作用。
将处于不同生长阶段的变形链球菌生物膜暴露于不同浓度（5、10和50微摩尔/升）的XTZ中，并进行不同时间（1、10、30和60分钟）的暴露。结果表明，XTZ去除变形链球菌生物膜的活性取决于浓度、暴露时间和生物膜的生长阶段。5微摩尔/升的XTZ浓度在变形链球菌生长的黏附阶段完全抑制了生物膜的形成，而当50微摩尔/升的XTZ暴露于变形链球菌生物膜60分钟时，在平台积累阶段去除了76%的生物膜。
从可食用植物（郁金）中分离出的莪术二酮显示出作为一种抗菌剂在体外抑制和去除变形链球菌生物膜的潜力。
XTZ可作为一种潜在的抗菌剂来对抗变形链球菌生物膜的形成。
