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来自于具有抗生素活性的金合欢烷型倍半萜类化合物 。 你提供的原文似乎不完整，“from”后面缺少具体内容。

Farnesane-Type Sesquiterpenoids with Antibiotic Activity from .

作者信息

Masi Marco, Roscetto Emanuela, Cimmino Alessio, Catania Maria Rosaria, Surico Giuseppe, Evidente Antonio

机构信息

Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, via Cintia 4, 80126 Napoli, Italy.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy.

出版信息

Antibiotics (Basel). 2021 Feb 2;10(2):148. doi: 10.3390/antibiotics10020148.

DOI:10.3390/antibiotics10020148
PMID:33540688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7913021/
Abstract

Brullo is an Asteraceae plant species endemic to Lampedusa island, the largest island of the Pelage archipelago, Italy. The organic extract of its whole aerial parts, showing antibiotic activity against and , wasfractionated employing bioguided purification procedures affording three main farnesane-type sesquiterpenoids. They were identified by spectroscopic methods (NMR and ESIMS data) as the ()-3,7,11-trimethyldodeca-1,6,10-triene-3,9-diol, ()-10-hydroxy-2,6,10-trimethyldodeca-2,6,11- trien-4-one and ()-10-hydroxy-2,6,10-trimethyl-dodeca-6,11-dien-4-one, commonly named 9-hydroxynerolidol, 9-oxonerolidol, and chiliadenol B, respectively. These three sesquiterpenes, isolated for the first time from , were tested on methicillin-resistant and showing antibacterial and antibiofilm activities. This plant could be used as a source to isolate secondary metabolites as potential new antibiotics.

摘要

布鲁洛是一种菊科植物，原产于意大利佩拉杰群岛最大的岛屿兰佩杜萨岛。其地上全株的有机提取物对[具体细菌1]和[具体细菌2]具有抗菌活性，采用生物导向纯化程序进行分离，得到了三种主要的金合欢烷型倍半萜类化合物。通过光谱方法（核磁共振和电喷雾离子化质谱数据）将它们鉴定为（）-3,7,11-三甲基十二碳-1,6,10-三烯-3,9-二醇、（）-10-羟基-2,6,10-三甲基十二碳-2,6,11-三烯-4-酮和（）-10-羟基-2,6,10-三甲基十二碳-6,11-二烯-4-酮，通常分别命名为9-羟基橙花叔醇、9-氧代橙花叔醇和辣椒二烯醇B。这三种倍半萜首次从[该植物名称]中分离出来，对耐甲氧西林的[具体细菌1]和[具体细菌2]进行了测试，显示出抗菌和抗生物膜活性。这种植物可作为分离次生代谢产物作为潜在新抗生素来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/b7cf760112f9/antibiotics-10-00148-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/6d8f1a7cf558/antibiotics-10-00148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/2d53789cbabc/antibiotics-10-00148-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/c91ef377bf15/antibiotics-10-00148-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/fbb1bebe7d93/antibiotics-10-00148-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/839f6f307c76/antibiotics-10-00148-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/b7cf760112f9/antibiotics-10-00148-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/6d8f1a7cf558/antibiotics-10-00148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/2d53789cbabc/antibiotics-10-00148-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/c91ef377bf15/antibiotics-10-00148-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/fbb1bebe7d93/antibiotics-10-00148-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/839f6f307c76/antibiotics-10-00148-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8263/7913021/b7cf760112f9/antibiotics-10-00148-g006.jpg

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