紫外线辐射对人眼和皮肤的急性影响。

Acute effects of UVR on human eyes and skin.

作者信息

Young Antony R

机构信息

St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London School of Medicine, at Guy's, King's College and St Thomas' Hospitals, London, UK.

出版信息

Prog Biophys Mol Biol. 2006 Sep;92(1):80-5. doi: 10.1016/j.pbiomolbio.2006.02.005. Epub 2006 Feb 28.

DOI:10.1016/j.pbiomolbio.2006.02.005

PMID:16600340

Abstract

Solar UVR ( approximately 295-400 nm) has acute clinical effects on the eyes and the skin. The only effect on the eye is inflammation of the cornea (photokeratitis), which is caused by UVB (and non-solar UVC) and resolves without long-term consequences within 48 h. The effects on the skin are more extensive and include sunburn (inflammation), tanning and immunosuppression for which UVB is mainly responsible. Tanning is modestly photoprotective against further acute UVR damage. Skin colour is also transiently changed by UVA-dependent immediate pigment darkening, the function of which is unknown. Skin type determines sensitivity to the acute and chronic effects of UVR on the skin. Some of the photochemical events that initiate acute effects are also related to skin cancer. Solar UVB is also responsible for the synthesis of vitamin D.

摘要

太阳紫外线辐射（约295 - 400纳米）对眼睛和皮肤有急性临床影响。对眼睛的唯一影响是角膜炎症（光角膜炎），这是由中波紫外线（和非太阳紫外线C）引起的，48小时内可自行消退，不会产生长期后果。对皮肤的影响更为广泛，包括晒伤（炎症）、晒黑和免疫抑制，其中主要由中波紫外线引起。晒黑对进一步的急性紫外线辐射损伤有一定的光保护作用。皮肤颜色也会因长波紫外线依赖的即时色素沉着而短暂改变，其功能尚不清楚。皮肤类型决定了皮肤对紫外线辐射急性和慢性影响的敏感性。引发急性影响的一些光化学事件也与皮肤癌有关。太阳中波紫外线还负责维生素D的合成。