Cooper M A, Andrews J M, Wise R
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
J Antimicrob Chemother. 1991 Sep;28(3):399-405. doi: 10.1093/jac/28.3.399.
The kill kinetics of sparfloxacin and ciprofloxacin have been investigated under anaerobic conditions against Bacteroides fragilis and Escherichia coli. The results for E. coli were compared with those obtained under aerobic conditions. It was found that the quinolones were bactericidal under anaerobic conditions. This bactericidal activity is inhibited by the presence of chloramphenicol, a known protein synthesis inhibitor. Filamentation was seen with B. fragilis after 2 h exposure to either agent.
在厌氧条件下，研究了司帕沙星和环丙沙星对脆弱拟杆菌和大肠杆菌的杀菌动力学。将大肠杆菌的结果与在需氧条件下获得的结果进行了比较。发现喹诺酮类药物在厌氧条件下具有杀菌作用。这种杀菌活性受到氯霉素（一种已知的蛋白质合成抑制剂）的抑制。脆弱拟杆菌在接触任何一种药物2小时后都出现了丝状化现象。
