环丙沙星、氧氟沙星、司帕沙星、替马沙星、CI-960、CI-990和WIN 57273对厌氧菌的比较活性。
Comparative activity of ciprofloxacin, ofloxacin, sparfloxacin, temafloxacin, CI-960, CI-990, and WIN 57273 against anaerobic bacteria.
作者信息
Goldstein E J, Citron D M
机构信息
R. M. Alden Research Laboratory, Santa Monica Hospital Medical Center, California 90404.
出版信息
Antimicrob Agents Chemother. 1992 May;36(5):1158-62. doi: 10.1128/AAC.36.5.1158.
Abstract
The in vitro activities of seven fluoroquinolones against 290 anaerobes were determined by agar dilution. CI-960 and WIN 57273 inhibited greater than 95% of the strains at less than or equal to 2 micrograms/ml. CI-990 required less than or equal to 16 micrograms/ml. Clustering around 2 to 4 micrograms/ml was noted for Bacteroides fragilis group organisms with CI-990, sparfloxacin, and temafloxacin. Temafloxacin and sparfloxacin inhibited most strains at less than or equal to 2 micrograms/ml. B. fragilis was more susceptible to all quinolones than were the other B. fragilis group strains.
摘要
采用琼脂稀释法测定了7种氟喹诺酮类药物对290株厌氧菌的体外活性。CI - 960和WIN 57273在浓度小于或等于2微克/毫升时可抑制超过95%的菌株。CI - 990所需浓度小于或等于16微克/毫升。对于脆弱拟杆菌群菌株，CI - 990、司帕沙星和替马沙星在2至4微克/毫升左右出现聚集现象。替马沙星和司帕沙星在浓度小于或等于2微克/毫升时可抑制大多数菌株。脆弱拟杆菌比其他脆弱拟杆菌群菌株对所有喹诺酮类药物更敏感。
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