Singh Meenakshi, Govindarajan Raghavan, Nath Virendra, Rawat Ajay Kumar Singh, Mehrotra Shanta
Bryology Laboratory, National Botanical Research Institute, Lucknow, India.
J Ethnopharmacol. 2006 Aug 11;107(1):67-72. doi: 10.1016/j.jep.2006.02.007. Epub 2006 Mar 6.
Plagiochasma appendiculatum (Aytoniaceae) of the order Marchantiales is widely used in the form of paste ethnomedicinally by Gaddi tribe in Kangra valley for treating skin diseases. In this context, antimicrobical potential of Plagiochasma appendiculatum against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing activity. The plant (alchoholic and aqueous extract) showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhimurium, and eight fungi Candida albicans and Cryptococcus albidus-dimorphic fungi, Trichophyton rubrum-dermatophyte fungi, Aspergillus niger, Aspergillus flavus, Aspergillus spinulosus, Aspergillus terreus and Aspergillus nidulans-systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Salmonella typhimurium) with an MIC of 2.5 microg/disc. The results show that Plagiochasma appendiculatum extract has potent wound healing capacity as evident from the wound contraction and increased tensile strength. The results also indicated that Plagiochasma appendiculatum extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and Catalase activity.
地钱目（Marchantiales）的附枝平盘苔（Aytoniaceae）被喜马偕尔邦康格拉山谷的加迪部落作为糊剂广泛用于民族医学中治疗皮肤病。在此背景下，研究了附枝平盘苔对多种微生物的抗菌潜力。为了验证该植物在皮肤病方面的民族治疗功效，除了研究其抗氧化活性以了解伤口愈合活性的机制外，还研究了伤口愈合活性。该植物（乙醇提取物和水提取物）对几乎所有测试微生物均表现出显著的抗菌和抗真菌活性：藤黄微球菌、枯草芽孢杆菌、蜡样芽孢杆菌、金黄色葡萄球菌、肺炎链球菌、产气肠杆菌、大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、铜绿假单胞菌、鼠伤寒沙门氏菌，以及八种真菌，白色念珠菌和浅白隐球菌（二态真菌）、红色毛癣菌（皮肤癣菌）、黑曲霉、黄曲霉、棘孢曲霉、土曲霉和构巢曲霉（系统性真菌），对皮肤癣菌（红色毛癣菌）和一些传染性细菌（大肠杆菌、奇异变形杆菌和鼠伤寒沙门氏菌）的活性尤其良好，最低抑菌浓度为2.5微克/圆盘。结果表明，附枝平盘苔提取物具有强大的伤口愈合能力，从伤口收缩和拉伸强度增加可明显看出。结果还表明，附枝平盘苔提取物通过抑制脂质过氧化以及增加超氧化物歧化酶（SOD）和过氧化氢酶活性而具有强大的抗氧化活性。
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