Pattanayak S P, Sunita P
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.
J Ethnopharmacol. 2008 Nov 20;120(2):241-7. doi: 10.1016/j.jep.2008.08.019. Epub 2008 Aug 23.
Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) of the order Santalales, is used ethnomedicinally for treating ulcers, asthma, impotence, paralysis, skin diseases, and wounds. In this context, validations of the ethnotherapeutic claims of the plant in wound healing activity was studied, besides anti-microbial activity and antioxidant activity were performed to understand the mechanism of wound healing potency. The ethanolic extract of aerial parts of Dendrophthoe falcata ethanolic extract (DFEE) was investigated for the evaluation of its healing efficiency on excision and incision wound models in rats. The results showed that Dendrophthoe falcata extract has potent wound healing capacity as evident from the wound contraction and increased tensile strength. Hydroxyproline and hexosamine expressions were also well correlative with the healing pattern observed. Three of the fractions A-C (petroleum ether, chloroform and ethanol, respectively) obtained from the extract exhibited significant antimicrobial activity against the organisms: Staphylococcus aureus, Staphylococcus pyogenes, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Klebsiella pneumoniae, Enterobacter aerogenes, Pseudomonas aeroginosa, Serratia marcescens, and five fungi Candida albicans, Candida tropicalis: dimorphic fungi, Aspergillus fumigatus, Aspergillus niger: systemic fungi, and some infectious bacteria Escherichia coli, and Salmonella typhi. The results also indicated that DFEE possesses potent antioxidant activity by inhibiting lipid peroxidation, reduced glutathione, superoxide dismutase levels and increased the catalase activity.
檀香目铁青树科的寄生藤（Dendrophthoe falcata (L.f) Ettingsh）在民族医学中被用于治疗溃疡、哮喘、阳痿、瘫痪、皮肤病和伤口。在此背景下，除了研究该植物在伤口愈合活性方面民族治疗主张的有效性外，还进行了抗菌活性和抗氧化活性研究，以了解其伤口愈合效能的机制。对寄生藤地上部分的乙醇提取物（DFEE）进行了研究，以评估其对大鼠切除和切开伤口模型的愈合效果。结果表明，寄生藤提取物具有强大的伤口愈合能力，从伤口收缩和拉伸强度增加可以明显看出。羟脯氨酸和氨基己糖的表达也与观察到的愈合模式密切相关。从提取物中获得的A - C三个馏分（分别为石油醚、氯仿和乙醇）对以下微生物表现出显著的抗菌活性：金黄色葡萄球菌、化脓性葡萄球菌、表皮葡萄球菌、藤黄微球菌、枯草芽孢杆菌、蜡样芽孢杆菌、肺炎克雷伯菌、产气肠杆菌、铜绿假单胞菌、粘质沙雷氏菌，以及五种真菌白色念珠菌、热带念珠菌（二态真菌）、烟曲霉、黑曲霉（系统性真菌），还有一些传染性细菌大肠杆菌和伤寒沙门氏菌。结果还表明，DFEE通过抑制脂质过氧化、降低谷胱甘肽、超氧化物歧化酶水平并提高过氧化氢酶活性，具有强大的抗氧化活性。
