Sureshkumar S V, Mishra S H
Pharmacy Department, Kalabhavan, The M.S. University of Baroda, Vadodara 390001, Gujarat, India.
J Ethnopharmacol. 2006 Sep 19;107(2):164-8. doi: 10.1016/j.jep.2006.02.019. Epub 2006 Apr 5.
Pergularia daemia (Asclepiadaceae) is a perennial herb growing widely along the road sides of India. It has been used in folk medicine for the treatment of liver disorders. The aim of this work is to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the aerial parts of Pergularia daemia. The aqueous and ethanolic extracts obtained from aerial parts of Pergularia daemia were evaluated for hepatoprotective activity in rats by inducing liver damage by carbon tetrachloride. The ethanolic extract at an oral dose of 200 mg/kg exhibited a significant (P<0.05) protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing the levels of total protein and albumin levels as compared to silymarin used as a positive control. These biochemical observations were supplemented by histopathological examination of liver sections. The activity may be a result of the presence of flavonoid compounds. Furthermore, the acute toxicity of the extracts showed no signs of toxicity up to a dose level of 2000 mg/kg. Thus it could be concluded that ethanolic extract of Pergularia daemia possesses significant hepatoprotective properties.
大白牛角瓜（萝摩科）是一种多年生草本植物，在印度的路边广泛生长。它在民间医学中被用于治疗肝脏疾病。这项工作的目的是研究大白牛角瓜地上部分的粗乙醇提取物和水提取物的保肝作用。通过用四氯化碳诱导大鼠肝损伤，对从大白牛角瓜地上部分获得的水提取物和乙醇提取物的保肝活性进行了评估。与用作阳性对照的水飞蓟宾相比，口服剂量为200mg/kg的乙醇提取物通过降低血清谷氨酸草酰乙酸转氨酶、谷氨酸丙酮酸转氨酶、碱性磷酸酶、总胆红素和总胆固醇水平，并提高总蛋白和白蛋白水平，表现出显著（P<0.05）的保护作用。这些生化观察结果得到了肝脏切片组织病理学检查的补充。该活性可能是黄酮类化合物存在的结果。此外，提取物的急性毒性在剂量水平达到2000mg/kg时未显示出毒性迹象。因此，可以得出结论，大白牛角瓜的乙醇提取物具有显著的保肝特性。
