Tomek Ales, Cizinauskas Sigitas, Doherr Marcus, Gandini Gualtiero, Jaggy André
Department of Clinical Veterinary Medicine, Division of Animal Neurology, University of Bern, Switzerland.
J Feline Med Surg. 2006 Aug;8(4):243-53. doi: 10.1016/j.jfms.2006.01.005.
The purpose of this study was to analyse retrospectively a feline population with intracranial neoplastic diseases, to document seizure patterns in these animals and to determine whether partial seizures were more frequently associated with structural brain lesions then generalised seizures. In addition, a comparison was made within the population with intracranial neoplasia between two groups of cats: one with and one without seizures. Special emphasis was given to the evaluation of tumour type, localisation and size of the lesion and its correlation with seizure prevalence. Sixty-one cats with histopathological diagnosis of intracranial tumour were identified. Fourteen cats (23%; group A) had a history of seizure(s). Forty-seven cats (77%; group B) had no history of seizure(s). Generalised tonic-clonic seizures were seen in eight cats (57%) and were the most common seizure pattern in our cats with intracranial neoplasia. Clusters of seizures were observed in six cats. Status epilepticus was observed in one patient. The mean age of the cats was 7.9 years within group A (median 8.5) and 9.3 years (median 10) within group B. The cats with lymphoma within both groups were significantly younger than cats with meningioma. In both groups meningioma and lymphoma were confirmed to be the most frequent tumour type, followed by glial cell tumours. The prevalence of the seizures in patients with glial cell tumours was 26.7%, 26.3% in patients with lymphomas and 15% in cases with meningiomas. In 33 cases (54.1%) the tumours were localised in the forebrain, 15 tumours (24.6%) were in the brainstem, four (6.6%) in the cerebellum and nine tumours (14.7%) had multifocal localisation. Parietal lobe and basal ganglia mostly affected group A. In group B tumours were most frequently located in the parietal and frontal lobes as well as in the diencephalon. A positive association was documented between the localisation of a tumour in the forebrain and seizure occurrence.
本研究的目的是对患有颅内肿瘤疾病的猫群进行回顾性分析，记录这些动物的癫痫发作模式，并确定部分性癫痫发作是否比全身性癫痫发作更常与脑结构性病变相关。此外，对患有颅内肿瘤的猫群中的两组进行了比较：一组有癫痫发作，另一组没有。特别强调了对肿瘤类型、病变的定位和大小及其与癫痫发作患病率的相关性的评估。确定了61只经组织病理学诊断为颅内肿瘤的猫。14只猫（23%；A组）有癫痫发作史。47只猫（77%；B组）无癫痫发作史。8只猫（57%）出现全身性强直阵挛性发作，是我们患有颅内肿瘤的猫中最常见的癫痫发作模式。6只猫观察到癫痫发作簇。1例患者出现癫痫持续状态。A组猫的平均年龄为7.9岁（中位数8.5岁），B组为9.3岁（中位数10岁）。两组中患有淋巴瘤的猫比患有脑膜瘤的猫明显年轻。两组中均证实脑膜瘤和淋巴瘤是最常见的肿瘤类型，其次是胶质细胞瘤。胶质细胞瘤患者的癫痫发作患病率为26.7%，淋巴瘤患者为26.3%，脑膜瘤患者为15%。33例（54.1%）肿瘤位于前脑，15例（24.6%）位于脑干，4例（6.6%）位于小脑，9例（14.7%）有多灶性定位。顶叶和基底神经节最常影响A组。B组中肿瘤最常位于顶叶和额叶以及间脑。肿瘤在前脑的定位与癫痫发作之间存在正相关。
