Qahwash Muna, Heller Heidi L Barnes
J Am Vet Med Assoc. 2018 Sep 15;253(6):763-767. doi: 10.2460/javma.253.6.763.
OBJECTIVE To identify seizure etiologic classification for cats that developed seizures at < 12 months of age and describe the long-term outcome of affected cats. DESIGN Retrospective cohort study. ANIMALS 15 client-owned cats with seizures that began at < 12 months of age. PROCEDURES Information on each cat was obtained from the medical records, veterinarians, and owners. Inclusion required an onset of seizures before 12 months of age and a complete medical record, including a final diagnosis. RESULTS 7 of the 15 cats had structural epilepsy, 4 had idiopathic epilepsy, and 4 had reactive seizures. Median age at seizure onset was 27 weeks (range, 0.4 to 41 weeks). Cluster seizures were reported in 6 cats, and status epilepticus was reported in 2. Age at the onset of seizures, presence of cluster seizures, and seizure semiology (ie, generalized vs focal seizures) were not significantly associated with seizure etiologic classification. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that cats that developed seizures at < 12 months of age were more likely to have structural epilepsy than idiopathic epilepsy or reactive seizures. Therefore, advanced diagnostic imaging is recommended in cats with juvenile-onset seizures if metabolic and toxic causes are excluded.
目的 确定12月龄前出现癫痫发作的猫的癫痫病因分类，并描述患猫的长期预后。设计 回顾性队列研究。动物 15只客户拥有的12月龄前开始出现癫痫发作的猫。程序 从病历、兽医和主人处获取每只猫的信息。纳入标准要求癫痫发作始于12月龄前且有完整的病历，包括最终诊断。结果 15只猫中7只患有结构性癫痫，4只患有特发性癫痫，4只患有反应性癫痫。癫痫发作的中位年龄为27周（范围为0.4至41周）。6只猫报告有丛集性发作，2只报告有癫痫持续状态。癫痫发作的年龄、丛集性发作的存在以及癫痫发作症状学（即全身性发作与局灶性发作）与癫痫病因分类无显著相关性。结论及临床意义 结果表明，12月龄前出现癫痫发作的猫比特发性癫痫或反应性癫痫更易患结构性癫痫。因此，如果排除代谢和中毒原因，建议对幼年发作癫痫的猫进行高级诊断成像检查。
