Pinhas-Hamiel Orit, Chernausek Steven D, Zeitler Philip
Pediatric Endocrinology and Diabetes, Sheba Medical Center, Ramat-Gan and Maccabi Juvenile Diabetes Center, Raanana, Israel.
Curr Opin Pediatr. 2006 Apr;18(2):206-8. doi: 10.1097/01.mop.0000193286.79399.43.
The demographics of diabetes among adolescents are changing, with an increasing prevalence of type 2 diabetes. Since adolescents with type 2 diabetes are susceptible to the same complications that accompany type 2 diabetes in adults, pediatricians are now encountering new diagnosis entities.
A 16-year-old Hispanic male presented to the emergency room with new onset diabetes. Laboratory evaluation revealed the diagnosis of hyperglycemic hyperosmolar nonketotic state. Within the next 24 hours, the patient's clinical status deteriorated with multi organ failure, followed by asystole. At autopsy, the pancreas demonstrated acute necrotising pancreatitis. Hyperglycemic hyperosmolar nonketotic state is a life-threatening emergency among adults with type 2 diabetes, and is now occurring more frequently among adolescents. Acute pancreatitis should be considered as a precipitating event, particularly in those with severe hypertriglyceridemia.
This case illustrates the changing morbidity of diabetes in adolescents and the need to consider acute pancreatitis and hyperglycemic hyperosmolar nonketotic in adolescents with severe metabolic decompensation. Since hypertriglyceridemia is a known risk factor for acute pancreatitis, patients should be monitored, and treated as needed.
青少年糖尿病的人口统计学特征正在发生变化,2型糖尿病的患病率不断上升。由于患有2型糖尿病的青少年易患与成人2型糖尿病相同的并发症,儿科医生现在遇到了新的诊断实体。
一名16岁的西班牙裔男性因新发糖尿病就诊于急诊室。实验室检查确诊为高血糖高渗非酮症状态。在接下来的24小时内,患者的临床状况因多器官衰竭而恶化,随后出现心搏停止。尸检显示胰腺为急性坏死性胰腺炎。高血糖高渗非酮症状态在患有2型糖尿病的成人中是一种危及生命的急症,现在在青少年中也越来越频繁地出现。应将急性胰腺炎视为一个促发事件,尤其是在那些患有严重高甘油三酯血症的患者中。
本病例说明了青少年糖尿病发病率的变化,以及在患有严重代谢失代偿的青少年中需要考虑急性胰腺炎和高血糖高渗非酮症状态。由于高甘油三酯血症是急性胰腺炎的已知危险因素,应对患者进行监测,并根据需要进行治疗。