Birk Thomas, Mundt Kenneth A, Dell Linda D, Luippold Rose S, Miksche Leopold, Steinmann-Steiner-Haldenstaett Wolfgang, Mundt Diane J
ENVIRON Germany GmbH, Essen, Germany.
J Occup Environ Med. 2006 Apr;48(4):426-33. doi: 10.1097/01.jom.0000194159.88688.f8.
We conducted a mortality study of two German chromate production facilities and evaluated possible dose-response relationships between hexavalent chromium exposure and lung cancer.
Mortality was followed-up through 1998 and limited to those employed since each plant converted to a no-lime production process. More than 12,000 urinalysis results of chromium levels were available, as was smoking information.
All-cause mortality indicated a healthy worker effect (standardized mortality ratio [SMR] = 0.80, 95% confidence interval [CI] = 0.67-0.96); however, lung cancers appeared to be increased (SMR = 1.48, 95% CI = 0.93-2.25). No clear dose-response was found in stratified analyses by duration of employment and time since hire. On the basis of urinary chromium data, lung cancer risk was elevated only in the highest exposure group (SMR = 2.09, 95% CI = 1.08-3.65).
These data suggest a possible threshold effect of occupational hexavalent chromium exposure on lung cancer.
我们对两家德国铬酸盐生产设施进行了死亡率研究，并评估了六价铬暴露与肺癌之间可能的剂量反应关系。
随访至1998年的死亡率，且仅限于自每家工厂转换为无石灰生产工艺后受雇的人员。有超过12000份尿液铬水平分析结果以及吸烟信息。
全因死亡率显示出健康工人效应（标准化死亡比[SMR]=0.80，95%置信区间[CI]=0.67 - 0.96）；然而，肺癌似乎有所增加（SMR = 1.48，95% CI = 0.93 - 2.25）。在按就业时长和入职时间分层分析中未发现明确的剂量反应。基于尿液铬数据，仅在最高暴露组肺癌风险升高（SMR = 2.09，95% CI = 1.08 - 3.65）。
这些数据表明职业性六价铬暴露对肺癌可能存在阈值效应。
