Vicario Javier, Walko Martin, Meetsma Auke, Feringa Ben L
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
J Am Chem Soc. 2006 Apr 19;128(15):5127-35. doi: 10.1021/ja058303m.
The introduction of bulky substituents at the stereogenic center of light-driven second-generation molecular motors results in an acceleration of the speed of rotation. This is due to a more strained structure with elongated C=C bonds and a higher energy level of the ground state relative to the transition state for the rate-limiting thermal isomerization step. Understanding the profound influence that variation of the substituent at the stereogenic center holds over the rotational speed of the light-driven molecular motor has enabled the development of the fastest molecular motor reported thus far.
在光驱动第二代分子马达的手性中心引入庞大取代基会导致旋转速度加快。这是由于结构应变更大，碳碳双键伸长，且相对于限速热异构化步骤的过渡态，基态具有更高的能级。了解手性中心取代基的变化对光驱动分子马达旋转速度的深远影响，使得迄今报道的最快分子马达得以开发。
