Iwamuro Masaya, Hiraoka Sakiko, Okada Hiroyuki, Kawai Yoshinari, Miyabe Yoshio, Takata Katsuyoshi, Kawano Seiji, Yamamoto Kazuhide
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Department of Gastroenterology, Onomichi Municipal Hospital, Onomichi, 722-8503, Japan.
Int J Colorectal Dis. 2016 Feb;31(2):313-7. doi: 10.1007/s00384-015-2392-6. Epub 2015 Sep 26.
The purpose of this study was to determine the prevalence of lymphoid hyperplasia in the lower gastrointestinal tract and its role in patients undergoing colonoscopic examinations, particularly focusing on any allergic predisposition.
A database search performed at the Department of Gastroenterology at Onomichi Municipal Hospital identified seven patients with lymphoid hyperplasia in the large intestine (i.e., cecum, colon, and/or rectum). Data regarding the endoscopic, biological, and pathological examinations performed and the allergic histories for each patient were retrospectively reviewed from the clinical records.
Median age of the patients (four males, three females) was 50 years. Lymphoid hyperplasia was seen in the cecum (n = 5), ascending colon (n = 2), and transverse colon (n = 1). Six patients (85.7%) had one of the allergic airway diseases: allergic rhinoconjunctivitis for pollen (n = 3), bronchial asthma (n = 1), infantile asthma (n = 1), or allergic bronchitis (n = 1). Drug allergy (n = 3) and urticaria (n = 2) were also found. All seven patients had one or more allergic diseases; however, none had a history of food allergy. Blood tests for allergens revealed that six patients (85.7%) had positive reactions to inherent allergens, whereas only one patient had a positive reaction to food allergens.
Our results indicate that lymphoid hyperplasia in the large intestine may be associated with allergic airway diseases rather than with food allergies; thus, its presence may be useful to detect patients with underlying airway hyperreactivity.
本研究旨在确定下消化道淋巴组织增生的患病率及其在接受结肠镜检查患者中的作用，尤其关注任何过敏易感性。
尾道市立医院胃肠病科进行的数据库检索确定了7例大肠（即盲肠、结肠和/或直肠）淋巴组织增生患者。从临床记录中回顾性分析了每位患者的内镜、生物学和病理检查数据以及过敏史。
患者（4名男性，3名女性）的中位年龄为50岁。淋巴组织增生见于盲肠（n = 5）、升结肠（n = 2）和横结肠（n = 1）。6例患者（85.7%）患有过敏性气道疾病之一：花粉过敏性鼻结膜炎（n = 3）、支气管哮喘（n = 1）、婴儿哮喘（n = 1）或过敏性支气管炎（n = 1）。还发现药物过敏（n = 3）和荨麻疹（n = 2）。所有7例患者都有一种或多种过敏性疾病；然而，没有人有食物过敏史。过敏原血液检测显示，6例患者（85.7%）对固有过敏原呈阳性反应，而只有1例患者对食物过敏原呈阳性反应。
我们的结果表明，大肠淋巴组织增生可能与过敏性气道疾病而非食物过敏有关；因此，其存在可能有助于检测潜在气道高反应性的患者。
