衍生化不影响灵芝属中扁芝酸和甾醇的抗菌和抗真菌活性。

Derivatization does not influence antimicrobial and antifungal activities of applanoxidic acids and sterols from Ganoderma spp.

作者信息

Smania Júnior Artur, Smania Elza F A, Della Monache Franco, Pizzolatti Moacir G, Delle Monache Giuliano

机构信息

Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis, SC 88040-900, Brazil.

出版信息

Z Naturforsch C J Biosci. 2006 Jan-Feb;61(1-2):31-4. doi: 10.1515/znc-2006-1-206.

DOI:10.1515/znc-2006-1-206

PMID:16610213

Abstract

Applanoxidic acids and sterols, isolated from Ganoderma spp., were acetylated and/or methylated. The antibacterial activity against Escherichia coli and Staphylococcus aureus and the antifungal activity against Candida albicans and Trichophyton mentagrophytes of the derivatives were investigated by a microdilution method, and compared with those of the natural products. Both natural and modified compounds exhibited comparable antibacterial and antifungal activities in a range of 1.0 to > 2.0 mg/ml minimal inhibitory concentration.

摘要

从灵芝属物种中分离出的扁芝酸和甾醇被进行了乙酰化和/或甲基化处理。通过微量稀释法研究了这些衍生物对大肠杆菌和金黄色葡萄球菌的抗菌活性以及对白色念珠菌和须癣毛癣菌的抗真菌活性，并与天然产物的活性进行了比较。天然化合物和改性化合物在1.0至>2.0mg/ml的最低抑菌浓度范围内均表现出相当的抗菌和抗真菌活性。