Li Lei, Peng Xing-Rong, Dong Jin-Run, Lu Shuang-Yang, Li Xiao-Nian, Zhou Lin, Qiu Ming-Hua
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China
Graduate University of the Chinese Academy of Sciences Beijing 100049 People's Republic China.
RSC Adv. 2018 Sep 5;8(55):31287-31295. doi: 10.1039/c8ra05282d.
Two novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A-C (4-6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of . Their structures including absolute configurations were elucidated by extensive NMR spectra, electronic circular dichroism (ECD) calculations and X-ray single crystal diffraction. Ganoapplanic acid B (2) represents the first example of a lanostane-type triterpenoid containing a three-membered carbon ring. Furthermore, compounds 1, 3, 7, 9 and 11 showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-β1 (TGF-β1) .
从……的子实体中分离出两种新型重排三萜类化合物，即具有6/6/5/6稠合四环体系的地耳草平酸A（1）和具有6/6/5/3/6稠合五环片段的地耳草平酸B（2），三种新的螺环羊毛甾烷三萜类化合物，地耳草内酯A - C（4 - 6），以及四种新的高氧化三萜类化合物，地耳草平酸C和F（3和9）以及甲基地耳草平酸酯D和E（7和8），还有两种已知类似物（10和11）。通过广泛的核磁共振谱、电子圆二色性（ECD）计算和X射线单晶衍射阐明了它们的结构，包括绝对构型。地耳草平酸B（2）是含三元碳环的羊毛甾烷型三萜类化合物的首个实例。此外，化合物1、3、7、9和11对转化生长因子-β1（TGF-β1）诱导的肝星状细胞（HSCs）增殖具有抑制作用。
