来自白柿的生物活性三萜类化合物。

Bioactive triterpenes from Diospyros blancoi.

作者信息

Ragasa Consolacion Y, Puno Marc Rhyan Anthony, Sengson Josephine Marie Angeline P, Shen Chien-Chang, Rideout John A, Raga Dennis D

机构信息

Chemistry Department, Center for Natural Sciences and Ecological Research, De La Salle University, 1004 Manila, Philippines.

出版信息

Nat Prod Res. 2009;23(13):1252-8. doi: 10.1080/14786410902951054.

DOI:10.1080/14786410902951054

PMID:19731144

Abstract

The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.

摘要

乌木风干叶片的乙酸乙酯提取物得到了异乔木醇甲醚（1）、α-香树脂醇棕榈酸酯、α-香树脂醇棕榈油酸酯、β-香树脂醇棕榈酸酯和β-香树脂醇棕榈油酸酯的混合物（2），其比例为13:4:3:1，以及角鲨烯。通过广泛的一维和二维核磁共振光谱对1、2和角鲨烯的结构进行了阐明。化合物1和2对大肠杆菌、铜绿假单胞菌、白色念珠菌、金黄色葡萄球菌和须癣毛癣菌表现出抗菌活性，且发现对枯草芽孢杆菌和黑曲霉无活性。样品2表现出显著的镇痛和抗炎活性。