Limkittikul Kriengsak, Yingsakmongkon Sangchai, Jittmittraphap Akanitt, Chuananon Somchai, Kongphrai Yuphin, Kowasupathr Surasak, Rojanawatsirivit Chaiyaporn, Mammen Mammen P, Jampangern Wipawee
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 2005 Nov;36(6):1432-8.
The objective of this study was to compare the clinical spectra of the dengue serotypes proven by the PCR technique. This retrospective study reviewed the clinical information of dengue-infected patients who were admitted to northeastern provincial hospitals in Thailand from June to September 2002. Dengue infection and viral serotypes were confirmed by polymerase chain reaction (PCR). Paired anti-dengue immunoglobulin G (IgG) and IgM from paired sera were analyzed by enzyme-linked immunosorbent assay (ELISA). Ninety-nine PCR-proven dengue-infected Thai patients were studied. Their ages ranged from 3-30 years. They were infected with DEN1, DEN2, DEN3 and DEN4 in 21, 55, 12, and 12%, respectively. Twenty-two percent had primary and 78% had secondary infections. Dengue fever was the most common presentation for both primary (77.2%) and secondary infections (46.7%). The ratios of dengue fever:dengue hemorrhagic fever (DF:DHF) and non-dengue shock syndrome:dengue shock syndrome (non-DSS:DSS) for DEN2 was the lowest of the dengue serotypes. There was no difference in the duration of fever, percentage of hepatomegaly and bleeding among the serotypes in both DF and DHF. The trends in the white blood cells, lymphocyte and atypical lymphocyte counts in DEN3 were the highest, while those of DEN1 were the lowest of the dengue serotypes.
本研究的目的是比较经聚合酶链反应（PCR）技术证实的登革热血清型的临床谱。这项回顾性研究回顾了2002年6月至9月入住泰国东北部省级医院的登革热感染患者的临床信息。登革热感染和病毒血清型通过聚合酶链反应（PCR）得以确认。采用酶联免疫吸附测定（ELISA）对配对血清中的配对抗登革热免疫球蛋白G（IgG）和IgM进行分析。对99例经PCR证实的登革热感染泰国患者进行了研究。他们的年龄在3至30岁之间。他们感染登革热1型（DEN1）、登革热2型（DEN2）、登革热3型（DEN3）和登革热4型（DEN4）的比例分别为21%、55%、12%和12%。22%为初次感染，78%为二次感染。登革热是初次感染（77.2%）和二次感染（46.7%）中最常见的表现形式。登革热2型的登革热：登革出血热（DF:DHF）以及非登革休克综合征：登革休克综合征（non-DSS:DSS）的比例在登革热血清型中是最低的。在登革热和登革出血热中，各血清型之间的发热持续时间、肝肿大百分比和出血百分比均无差异。登革热3型的白细胞、淋巴细胞和非典型淋巴细胞计数的变化趋势在登革热血清型中是最高的，而登革热1型的则是最低的。
