Yuen P H, Matherne C M, Molinari-Storey L M
Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Smithville 78957.
Am J Pathol. 1991 Dec;139(6):1449-61.
SV7, a progeny of Moloney murine sarcoma virus 349 cells, was molecularly cloned. SV7 induced sarcomas consisting of vascular and fibrous components. The large blood-filled vascular dilatations appeared grossly as dark red spots in the tumors and constituted up to 50% of the tumor volume. These vascular structures, ranging from small capillaries to cavernous vascular dilatations, were lined by one to several layers of neoplastic endothelial cells. Thick papillary outgrowths of the neoplastic endothelium extended into and often occluded the vessel lumens. The fibrous component consisted mostly of spindle cells and granulocytes, which provided the stroma for the vascular structures. The vascular and fibrous components appeared to have arisen independently. Lymphopenia accompanied by myeloid metaplasia was observed in the spleen of both SV7- and myeloproliferative sarcoma virus (MPSV)-infected mice. The blood of SV7-infected mice had a much higher level of circulating granulocytes than did that of MPSV-infected mice. The latter manifested a more advanced myeloid metaplasia, characterized by aggregates of myelomonocytic blast cells in the spleen.
SV7是莫洛尼鼠肉瘤病毒349细胞的子代病毒，已进行分子克隆。SV7诱导形成的肉瘤由血管和纤维成分组成。大量充满血液的血管扩张在肿瘤大体上表现为暗红色斑点，占肿瘤体积的50%。这些血管结构从小毛细血管到海绵状血管扩张不等，内衬一层到几层肿瘤性内皮细胞。肿瘤性内皮细胞的厚乳头样突起延伸至血管腔并常常阻塞管腔。纤维成分主要由梭形细胞和粒细胞组成，为血管结构提供间质。血管和纤维成分似乎是独立产生的。在感染SV7和骨髓增殖性肉瘤病毒（MPSV）的小鼠脾脏中均观察到伴有髓外化生的淋巴细胞减少。与感染MPSV的小鼠相比，感染SV7的小鼠血液中循环粒细胞水平要高得多。后者表现出更晚期的髓外化生，其特征是脾脏中有髓单核母细胞聚集。
