Geisthoff U W, Fiorella M L, Fiorella R
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universitätskliniken des Saarlandes, Homburg/Saar, Germany.
Curr Pharm Des. 2006;12(10):1237-42. doi: 10.2174/138161206776361255.
No optimal treatment modality is currently available for the treatment of recurrent epistaxis in HHT. In this review, different therapeutic concepts are discussed together with their pathophysiologic background. Patients often profess a preventive effect for nasal ointments and use packings which can be self-administered in the case of bleeding. An effective first-line treatment for physicians is the endonasal laser coagulation or argon plasma coagulation. A second line surgical procedure is septodermoplasty according to Saunders which can provide long-lasting relief if performed correctly. There have been reports on antifibrinolytic agents and hormones, but their efficacy has yet to be determined.
目前尚无针对遗传性出血性毛细血管扩张症（HHT）复发性鼻出血的最佳治疗方式。在本综述中，将讨论不同的治疗理念及其病理生理背景。患者常称鼻用软膏有预防作用，并会使用在出血时可自行应用的填塞物。对医生而言，有效的一线治疗方法是鼻内激光凝固或氩等离子体凝固。二线外科手术是根据桑德斯方法进行的鼻中隔皮成形术，如果操作正确，可提供持久缓解。已有关于抗纤维蛋白溶解剂和激素的报道，但其疗效尚未确定。
