Shekar Sri Niranjan, Banerjee Tathagata, Biswas Atanu
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Twin Res Hum Genet. 2006 Feb;9(1):73-5. doi: 10.1375/183242706776403037.
Previous studies have shown that Glutathione, a tripeptide found in blood, is involved in protecting against toxins. Glutathione levels are known to drop in response to cadmium. Using 15 twin pairs, we modeled the effect of cadmium on glutathione levels. The heritability of glutathione content was 91%. The application of cadmium significantly reduced the mean level of GSH. However, this reduction in GSH was not due to additive genetic influences in our sample.
先前的研究表明，谷胱甘肽（一种存在于血液中的三肽）参与了对毒素的防护。已知谷胱甘肽水平会因镉而下降。我们使用15对双胞胎，模拟了镉对谷胱甘肽水平的影响。谷胱甘肽含量的遗传率为91%。镉的应用显著降低了谷胱甘肽（GSH）的平均水平。然而，在我们的样本中，GSH的这种降低并非由于加性遗传影响。
