Tanda M L, Lombardi V, Genovesi M, Ultimieri F, Lai A, Gandolfo M, Dalle Mule I, Grasso L, Bogazzi F, Broglio F, Ghigo E, Martino E, Bartalena L
Division of Endocrinology, Department of Clinical Medicine, University of Insubria, 21100 Varese, Italy.
J Endocrinol Invest. 2009 Jan;32(1):74-8. doi: 10.1007/BF03345683.
Results of circulating Ghrelin levels in hyper- or hypothyroidism are conflicting and only overt thyroid dysfunction has been evaluated.
To evaluate in a large number of patients with thyroid disfunction whether: a) hyper- and hypothyroidism (clinical or subclinical) are associated with variations in both acylated (AG) and total Ghrelin (TG) concentrations, and b) correction of thyroid dysfunction is followed by variations in Ghrelin concentrations.
Seventy-six hyperthyroids, 52 hypothyroids, 144 euthyroids with chronic autoimmune thyroiditis, and 109 euthyroid healthy controls were evaluated cross-sectionally and longitudinally.
TG and AG were significantly lower in hyperthyroids than in controls or hypothyroids; the latter 2 groups did not differ. TG was significantly lower in overt than in subclinical hyperthyroids, with a trend to a reduction also in AG levels. No differences were found between subclinical hyperthyroids and controls. After thionamide treatment, TG and AG levels in hyperthyroids did not differ from controls. L-thyroxine management of hypothyroidism was not associated with significant Ghrelin variations. Plasma Ghrelin was independent of either thyroid or gastric autoimmunity. Plasma TG was negatively correlated with serum free thyroid hormone levels in hyperthyroids but not in hypothyroids.
Plasma Ghrelin concentrations are reduced in overt but not in subclinical hyperthyroidism and normalize after restoration of euthyroidism. Hypothyroidism is not accompanied by significant changes in circulating Ghrelin.
甲状腺功能亢进或减退时循环中胃饥饿素水平的结果存在矛盾，且仅对明显的甲状腺功能障碍进行了评估。
在大量甲状腺功能障碍患者中评估：a）甲状腺功能亢进和减退（临床或亚临床）是否与酰化胃饥饿素（AG）和总胃饥饿素（TG）浓度的变化有关，以及b）甲状腺功能障碍得到纠正后胃饥饿素浓度是否会发生变化。
对76例甲状腺功能亢进患者、52例甲状腺功能减退患者、144例患有慢性自身免疫性甲状腺炎的甲状腺功能正常者以及109例甲状腺功能正常的健康对照者进行了横断面和纵向评估。
甲状腺功能亢进患者的TG和AG显著低于对照组或甲状腺功能减退患者；后两组之间无差异。明显甲状腺功能亢进患者的TG显著低于亚临床甲状腺功能亢进患者，AG水平也有降低趋势。亚临床甲状腺功能亢进患者与对照组之间未发现差异。硫代酰胺治疗后，甲状腺功能亢进患者的TG和AG水平与对照组无差异。甲状腺功能减退患者使用左甲状腺素治疗与胃饥饿素的显著变化无关。血浆胃饥饿素与甲状腺或胃自身免疫无关。甲状腺功能亢进患者血浆TG与血清游离甲状腺激素水平呈负相关，而甲状腺功能减退患者则无此相关性。
明显甲状腺功能亢进时血浆胃饥饿素浓度降低，亚临床甲状腺功能亢进时则不然，甲状腺功能恢复正常后血浆胃饥饿素浓度恢复正常。甲状腺功能减退时循环中的胃饥饿素无显著变化。
