Ziegler K, Görl R, Effing J, Ellermann J, Mappes M, Otten S, Kapp H, Zoellner P, Spaeth D, Smola H
Paul Hartmann AG, Heidenheim, Germany.
Skin Pharmacol Physiol. 2006;19(3):140-6. doi: 10.1159/000092594. Epub 2006 Apr 6.
Bacterial colonisation of wounds may delay wound healing. Modern silver-containing dressings are antimicrobial, yet cellular toxicity is a serious side-effect. We provide data for a newly formulated silver-containing ointment dressing, Atrauman Ag, for antimicrobial activity and cytotoxicity. Atrauman Ag effectively killed a panel of commensal skin as well as pathogenic bacterial strains while cytotoxicity for HaCaT keratinocytes was only around 10%. With these favourable in vitro tests, Atrauman Ag was analysed in 86 patients with traumatic and non-healing wounds of different aetiologies. The wound state was evaluated for 3 subsequent dressing changes. The slough score was reduced from 59.2 to 35.8%, granulation tissue increased from 27 to 40% and epithelialisation went up from 12.1 to 24%. We conclude that Atrauman Ag has a superior profile of antimicrobial activity over cellular toxicity and the low silver ion release rate may prevent interference with wound-healing mechanisms.
伤口的细菌定植可能会延迟伤口愈合。现代含银敷料具有抗菌作用，但细胞毒性是一种严重的副作用。我们提供了一种新配方的含银软膏敷料Atrauman Ag的抗菌活性和细胞毒性数据。Atrauman Ag能有效杀死一组共生皮肤细菌以及病原菌，而对HaCaT角质形成细胞的细胞毒性仅约为10%。基于这些良好的体外试验结果，我们对86例不同病因的创伤性和不愈合伤口患者使用了Atrauman Ag进行分析。对随后3次换药时的伤口状态进行了评估。腐痂评分从59.2%降至35.8%，肉芽组织从27%增加到40%，上皮形成从12.1%上升到24%。我们得出结论，Atrauman Ag在抗菌活性方面优于细胞毒性，且低银离子释放率可能防止对伤口愈合机制的干扰。
