Zocratto Keli Bahia Felicíssimo, Caiaffa Waleska Teixeira, Proietti Fernando Augusto, Carneiro-Proietti Anna Bárbara, Mingoti Sueli Aparecida, Ribeiro Geraldo José Coelho
Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Cad Saude Publica. 2006 Apr;22(4):839-48. doi: 10.1590/s0102-311x2006000400022. Epub 2006 Apr 5.
This study aimed to characterize sexual and drug-use behaviors in injecting drug users (IDUs) in relation to single hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection and HCV/HIV co-infection. The sample consisted of 272 IDUs enrolled in the AjUDE-Brasil I Project, a cross-sectional multi-center study conducted in five Brazilian cities in 1998. Data were collected with a structured questionnaire using self-reported risk behavior, and HCV and HIV serological status used ELISA on filter paper. IDUs were clustered in four distinct groups: HCV/HIV seronegative; HCV mono-infected; HIV mono-infected; and HCV/HIV co-infected. Active sharing of injecting equipment was associated with HCV infection (p = 0.001). Sexual behavior variables, especially male same-sex sexual relations, were consistently associated with HIV infection. HCV/HIV co-infection was associated with both sexual and drug use variables. It was possible to distinguish different behavioral indicators for HCV and HIV infection and co-infection in this population.
本研究旨在描述注射吸毒者（IDU）的性行为和吸毒行为，这些行为与丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）的单一感染以及HCV/HIV合并感染相关。样本包括参与1998年在巴西五个城市开展的一项横断面多中心研究——AjUDE-巴西I项目的272名注射吸毒者。通过结构化问卷收集自我报告的风险行为数据，并用酶联免疫吸附测定法（ELISA）检测滤纸样本中的HCV和HIV血清学状态。注射吸毒者被分为四个不同组：HCV/HIV血清学阴性组；HCV单一感染组；HIV单一感染组；以及HCV/HIV合并感染组。共用注射器具与HCV感染相关（p = 0.001）。性行为变量，尤其是男性同性性关系，始终与HIV感染相关。HCV/HIV合并感染与性行为和吸毒变量均相关。在这一人群中，有可能区分出HCV感染、HIV感染及合并感染的不同行为指标。
