圣保罗坎皮纳斯市成人初发急性髓系白血病中FAB M1形态学亚型的高患病率。

High prevalence of morphological subtype FAB M1 in adults with de novo acute myeloid leukemia in São José dos Campos, São Paulo.

作者信息

Callera Fernando, Mulin Carla Cecília, Rosa Evandro Secchi, Melo Djanete Barbosa de, Melo Cláudio Marcelo Tavares Pessoa de

机构信息

Hospital Pio XII, São José dos Campos, São Paulo, Brazil.

出版信息

Sao Paulo Med J. 2006 Jan 5;124(1):45-7. doi: 10.1590/s1516-31802006000100010. Epub 2006 Apr 3.

DOI:10.1590/s1516-31802006000100010

PMID:16612463

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11060393/

Abstract

CONTEXT AND OBJECTIVE

Geographical variations have been described in acute myelogenous leukemia (AML). In Brazil, few studies have been published on this. The aim of this study was to demonstrate the high prevalence of French-American-British (FAB) M1 subtype in adults with de novo AML in São José dos Campos, State of São Paulo, Brazil.

DESIGN AND SETTING

Retrospective analysis, at Hospital Pio XII in São José dos Campos, a public non-teaching institution.

METHODS

Records from 39 consecutive adult patients with de novo AML referred to Hospital Pio XII between January 2002 and September 2004 were reviewed. Peripheral blood and blood marrow smears were reviewed blindly by five hematologists and classified according to FAB criteria. The rates of remission, relapse, mortality according treatment phase, survival and leukemia-free survival were calculated.

RESULTS

The prevalence of each category as determined via a consensus among five observers was M0: 0%; M1: 43.6%; M2: 30.7%; M3: 12.8%; M4: 5.1%; M5: 2.6%: M6: 2.6%; and M7: 2.6%. The remission and the relapse rates were 82% and 41% respectively. The mortality rate was 69% (induction of remission: 7/39, 17.9%; post induction: 10/32, 31.2%; and relapse: 10/16, 62.5%). The survival rate was 30% and leukemia-free survival was 33%.

CONCLUSIONS

The study demonstrated a high prevalence of FAB M1 subtype in adults with de novo AML in São José dos Campos. Our data suggest the occurrence of different regional prevalences of FAB AML categories in Brazil.

摘要

背景与目的

急性髓系白血病（AML）存在地域差异。在巴西，关于这方面的研究发表较少。本研究旨在证明在巴西圣保罗州圣若泽杜斯坎普斯市，初治成人AML患者中法国-美国-英国（FAB）M1亚型的高患病率。

设计与背景

在圣若泽杜斯坎普斯市的皮奥十二世医院进行回顾性分析，该医院是一家公立非教学机构。

方法

回顾了2002年1月至2004年9月期间转诊至皮奥十二世医院的39例连续初治成人AML患者的记录。5位血液学家对外周血和骨髓涂片进行盲法检查，并根据FAB标准进行分类。计算缓解率、复发率、各治疗阶段的死亡率、生存率和无白血病生存率。

结果

通过5位观察者的共识确定的各类型患病率为：M0：0%；M1：43.6%；M2：30.7%；M3：12.8%；M4：5.1%；M5：2.6%；M6：2.6%；M7：2.6%。缓解率和复发率分别为82%和41%。死亡率为69%（诱导缓解期：7/39，17.9%；诱导缓解后：10/32，31.2%；复发期：10/16，62.5%）。生存率为30%，无白血病生存率为33%。