Rathcke C N, Johansen J S, Vestergaard H
Department of Endocrinology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark.
Inflamm Res. 2006 Feb;55(2):53-9. doi: 10.1007/s00011-005-0010-8.
YKL-40 participates in inflammatory states and vascular processes, which implies that comparison can be made with other inflammatory markers associated with insulin resistance and type 2 diabetes (T2D). In the present study levels of plasma YKL-40 and serum hsCRP were evaluated in patients with T2D.
Patients with T2D and age-matched healthy controls participated in the study. Insulin resistance was estimated using HOMA-IR model. Biochemical parameters were measured in venous blood after a 10 h fast.
Patients with T2D were insulin resistant (p<0.001) and had raised levels of plasma YKL-40 (p<0.001) and serum hsCRP (p<0.001). YKL-40 was correlated with HOMA-IR (r=0.23, p<0.01), NEFA (r=0.32, p<0.001) and triglycerides (r=0.24, p<0.05). YKL-40 and hsCRP were not correlated (r=0.17, p=NS). All participants with hsCRP<1 mg/l had higher insulin sensitivity (p<0.05 and p<0.01, respectively). HsCRP were predicted by HOMA-IR and BMI (r2=0.48, p<0.01). Plasma YKL-40 was predicted by HOMA-IR and triglycerides (r2=0.27, p<0.01).
YKL-40 and hsCRP are elevated in patients with T2D and are related to insulin resistance. No correlation was found between YKL-40 and hsCRP indicating that increased levels of YKL-40 occur independently from elevated plasma hsCRP.
YKL-40参与炎症状态和血管过程，这意味着可与其他与胰岛素抵抗和2型糖尿病（T2D）相关的炎症标志物进行比较。在本研究中，对T2D患者的血浆YKL-40水平和血清hsCRP进行了评估。
T2D患者和年龄匹配的健康对照者参与了本研究。使用HOMA-IR模型评估胰岛素抵抗。禁食10小时后采集静脉血测量生化参数。
T2D患者存在胰岛素抵抗（p<0.001），血浆YKL-40水平升高（p<0.001），血清hsCRP水平升高（p<0.001）。YKL-40与HOMA-IR（r=0.23，p<0.01）、游离脂肪酸（NEFA，r=0.32，p<0.001）和甘油三酯（r=0.24，p<0.05）相关。YKL-40与hsCRP无相关性（r=0.17，p=无显著性差异）。所有hsCRP<1mg/l的参与者胰岛素敏感性更高（分别为p<0.05和p<0.01）。hsCRP可由HOMA-IR和BMI预测（r2=0.48，p<0.01）。血浆YKL-40可由HOMA-IR和甘油三酯预测（r2=0.27，p<0.01）。
T2D患者YKL-40和hsCRP升高，且与胰岛素抵抗相关。未发现YKL-40与hsCRP之间存在相关性，表明YKL-40水平升高独立于血浆hsCRP升高而发生。
