Henriques M, Azeredo J, Oliveira R
Centro de Engenharia Biológica - CEB, Universidade do Minho, Braga, Portugal.
Br J Biomed Sci. 2006;63(1):5-11. doi: 10.1080/09674845.2006.11732712.
Candida albicans and C. dubliniensis are two species responsible for oral candidiasis, especially in immunocompromised patients. Microbial infection is preceded by adherence and biofilm formation. Biofilm formation represents the most common form of C. albicans in the oral cavity and is considered to be one of the most important virulence factors. In this study, the biofilm formation ability of C. dubliniensis was compared with that of C. albicans in terms of biomass (quantified using crystal violet) and activity (assessed by formazan salts formation). Both species formed heterogeneous biofilms; however, species and strain variations were seen in the quantification of biomass and activity. There was no correlation between pseudohyphae formation and biofilm formation capability.
白色念珠菌和都柏林念珠菌是导致口腔念珠菌病的两种病原体，尤其在免疫功能低下的患者中。微生物感染之前会先发生黏附及生物膜形成。生物膜形成是口腔中白色念珠菌最常见的形式，被认为是最重要的毒力因子之一。在本研究中，就生物量（使用结晶紫定量）和活性（通过甲臜盐形成评估）而言，比较了都柏林念珠菌和白色念珠菌的生物膜形成能力。两种念珠菌均形成了异质性生物膜；然而，在生物量和活性的定量方面存在菌种和菌株差异。假菌丝形成与生物膜形成能力之间没有相关性。
