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本文引用的文献

1
Oral biofilm architecture on natural teeth.自然牙表面的口腔生物膜结构。
PLoS One. 2010 Feb 24;5(2):e9321. doi: 10.1371/journal.pone.0009321.
2
Oropharyngeal candidiasis in the era of antiretroviral therapy.抗逆转录病毒治疗时代的口腔念珠菌病
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):488-95. doi: 10.1016/j.tripleo.2009.11.026. Epub 2010 Feb 13.
3
The effect of gentian violet on virulent properties of Candida albicans.龙胆紫对白色念珠菌毒力特性的影响。
Mycopathologia. 2010 Apr;169(4):279-85. doi: 10.1007/s11046-009-9258-9. Epub 2009 Nov 24.
4
Parenteral lipid emulsion induces germination of Candida albicans and increases biofilm formation on medical catheter surfaces.肠外脂质乳剂可诱导白色念珠菌萌发，并增加其在医用导管表面的生物膜形成。
J Infect Dis. 2009 Aug 1;200(3):473-80. doi: 10.1086/600106.
5
In vitro growth and analysis of Candida biofilms.念珠菌生物膜的体外生长与分析
Nat Protoc. 2008;3(12):1909-24. doi: 10.1038/nprot.2008.192.
6
In vitro activity of inexpensive topical alternatives against Candida spp. isolated from the oral cavity of HIV-infected patients.从感染HIV患者口腔分离出的念珠菌属对廉价局部用替代药物的体外活性
Int J Antimicrob Agents. 2008 Mar;31(3):272-6. doi: 10.1016/j.ijantimicag.2007.11.008. Epub 2008 Feb 1.
7
Oral manifestations of HIV/AIDS in clients attending TASO clinics in Uganda.乌干达艾滋病服务组织（TASO）诊所中接受治疗的艾滋病病毒/艾滋病（HIV/AIDS）患者的口腔表现。
Clin Oral Investig. 2007 Sep;11(3):289-92. doi: 10.1007/s00784-007-0118-z. Epub 2007 May 3.
8
Oral candidiasis and oral yeast carriage among institutionalised South African paediatric HIV/AIDS patients.南非机构收容的儿科艾滋病毒/艾滋病患者中的口腔念珠菌病和口腔酵母菌携带情况。
Mycopathologia. 2007 Feb;163(2):67-73. doi: 10.1007/s11046-006-0087-9. Epub 2007 Feb 12.
9
Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols.白色念珠菌生物被膜中氟康唑耐药机制：外排泵和膜甾醇的阶段特异性作用
Infect Immun. 2003 Aug;71(8):4333-40. doi: 10.1128/IAI.71.8.4333-4340.2003.
10
Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.念珠菌生物膜的抗真菌药敏性：两性霉素B脂质制剂和棘白菌素的独特疗效
Antimicrob Agents Chemother. 2002 Jun;46(6):1773-80. doi: 10.1128/AAC.46.6.1773-1780.2002.

龙胆紫对从 HIV 感染患者获得的口腔念珠菌分离物形成的生物膜具有活性。

Gentian violet exhibits activity against biofilms formed by oral Candida isolates obtained from HIV-infected patients.

机构信息

Center for Medical Mycology, Department of Dermatology, Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

出版信息

Antimicrob Agents Chemother. 2011 Jun;55(6):3043-5. doi: 10.1128/AAC.01601-10. Epub 2011 Mar 28.

DOI:10.1128/AAC.01601-10
PMID:21444708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3101405/
Abstract

The effect of gentian violet against Candida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibit Candida albicans germination was also assessed. Gentian violet activity against Candida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibited Candida germination in a concentration-dependent manner.

摘要

采用干重分析法和共聚焦激光扫描显微镜评估了龙胆紫对聚甲基丙烯酸甲酯条上形成的白色念珠菌和非白色念珠菌生物膜的作用。还评估了龙胆紫抑制白色念珠菌发芽的能力。龙胆紫对白色念珠菌生物膜的活性表现为干重减少、生物膜结构破坏和生物膜厚度降低。此外，龙胆紫以浓度依赖的方式抑制了白色念珠菌的发芽。