Siebert L, Wanner J
Externe Psychiatrische Dienste Bruderholz, Baselland.
Ther Umsch. 2006 Mar;63(3):179-83. doi: 10.1024/0040-5930.63.3.179.
Antidepressants can also be useful for non-classical indications such as bereavement, burn out and pain, if these conditions lead into a depressive episode or if additional effects like modulation of pain are of therapeutic benefit. Due to the range of side-effects and potential interactions, present medical condition, medication and the clinical appearance of the depressive episode have to be taken into account for the choice of the specific antidepressant. Patients need to be thoroughly informed and accompanied to build and sustain compliance. Patient's sceptical attitude towards antidepressants must be taken seriously and the risk of treatment needs to be considered.
抗抑郁药对诸如居丧、倦怠和疼痛等非典型适应症也可能有用，前提是这些情况导致了抑郁发作，或者像疼痛调节这样的附加效应具有治疗益处。由于副作用范围和潜在相互作用，选择特定的抗抑郁药时必须考虑患者当前的病情、正在服用的药物以及抑郁发作的临床表现。需要让患者充分了解情况并给予陪伴，以建立和维持依从性。必须认真对待患者对抗抑郁药的怀疑态度，并考虑治疗风险。
