Donoval Betty A, Landay Alan L, Moses Stephen, Agot Kawango, Ndinya-Achola J O, Nyagaya Edith A, MacLean Ian, Bailey Robert C
Division of Epidemiology, School of Public Health, University of Illinois, Chicago 60612, USA.
Am J Clin Pathol. 2006 Mar;125(3):386-91.
Numerous epidemiologic studies have found significant associations between lack of circumcision and HIV-1 acquisition in men. To our knowledge, this is the first study of human foreskin tissue that examines biologic mechanisms that increase susceptibility of uncircumcised African men to HIV-1. Foreskin specimens from 20 men with and 19 men with no history of sexually transmitted infections were examined for HIV-1 target cells. Most Langerhans cells were found in the epithelium; most CD4+ T cells and macrophages were in the submucosa. There were no differences in HIV-1 target cells between men with and those without history of sexually transmitted infections. However Langerhans cells and macrophages were more abundant in the group with a history of infection. The densities and positions of HIV-1 target cells in the foreskin tissue of these Kenyan men indicate that the inner mucosal surface of the human foreskin contains cells that make it highly susceptible to HIV infection.
众多流行病学研究发现，男性未行包皮环切术与感染HIV-1之间存在显著关联。据我们所知，这是第一项针对人类包皮组织的研究，该研究探讨了未行包皮环切术的非洲男性易感染HIV-1的生物学机制。对20名有性传播感染史和19名无性传播感染史男性的包皮标本进行了HIV-1靶细胞检测。发现大多数朗格汉斯细胞位于上皮层；大多数CD4+T细胞和巨噬细胞位于黏膜下层。有性传播感染史的男性与无性传播感染史的男性在HIV-1靶细胞方面没有差异。然而，有感染史的组中朗格汉斯细胞和巨噬细胞更为丰富。这些肯尼亚男性包皮组织中HIV-1靶细胞的密度和位置表明，人类包皮的内黏膜表面含有使其极易感染HIV的细胞。
