Martynowicz Helena, Andrzejak Ryszard, Medraś Marek
Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadcisnienia Tetniczego AM we Wroclawiu.
Med Pr. 2005;56(6):495-500.
The deterioration of male fertility, found in numerous epidemiological studies of past decades, can be connected to growing exposure to environmental toxins. Heavy metals, especially lead is widely spread and extremely toxic. The mechanism by which lead exerts toxic effects on testis is quite complex. It involves spermatogenesis, steroidogenesis, and red-ox system. The chronic lead exposure can induce functional disorder (decrease of testosterone synthesis) or morphological disorder (decrease of testicular weight and seminal vesicle, peritubular fibrosis, seminiferous tubular diameter decrease and decrease in germ cell population related to an apoptotic process). Currently existing environmental and occupational exposure to lead and increasing combined exposure to environmental toxins results in constantly increasing number of diagnosed fertility impairments.
在过去几十年的众多流行病学研究中发现，男性生育能力的下降与日益接触环境毒素有关。重金属，尤其是铅广泛存在且毒性极强。铅对睾丸产生毒性作用的机制相当复杂。它涉及精子发生、类固醇生成和氧化还原系统。慢性铅暴露可导致功能紊乱（睾酮合成减少）或形态紊乱（睾丸重量和精囊减小、管周纤维化、曲细精管直径减小以及与凋亡过程相关的生殖细胞数量减少）。目前环境和职业性铅暴露的存在以及环境毒素联合暴露的增加，导致诊断出的生育障碍数量不断上升。
