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特发性少弱精子症男性精液中铅和镉与精液参数的相关性

Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males.

作者信息

Taha Emad A, Sayed Sohair K, Ghandour Nagwa M, Mahran Ali M, Saleh Medhat A, Amin Magdy M, Shamloul Rany

机构信息

Departments of Dermatology & Andrology.

Clinical Pathology.

出版信息

Cent European J Urol. 2013;66(1):84-92. doi: 10.5173/ceju.2013.01.art28. Epub 2013 Apr 26.

DOI:10.5173/ceju.2013.01.art28
PMID:24579002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3921854/
Abstract

INTRODUCTION

The exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role. Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions. The aim of this study was to evaluate lead and cadmium levels in seminal plasma of men with idiopathic oligoasthenozoospermia in comparison to fertile healthy controls and to correlate these levels with conventional semen parameters, sperm hypo-osmotic swelling (HOS) percentage, sperm DNA fragmentation percentage, and semen reactive oxygen species (ROS) levels.

MATERIAL AND METHODS

Thirty infertile male patients with idiopathic oligo and/or asthenozoospermia and thirty healthy fertile men, which was the control group, were included in the study. Lead and cadmium levels in seminal plasma, semen parameters, sperm HOS, sperm DNA fragmentation percentage and semen ROS assay were measured in all subjects.

RESULTS

There was a significant increase in seminal lead and cadmium levels among infertile males in comparison to controls. There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS). Importantly, significant positive correlations were noted between seminal lead and cadmium levels on one hand and sperm DNA fragmentation percentage and semen ROS level in infertile men and controls on the other hand.

CONCLUSIONS

Thus, men with idiopathic male infertility had higher levels of lead and cadmium in their semen which correlated with impairment of sperm motility and vitality percentages and more importantly with higher sperm DNA fragmentation% and semen ROS level.

摘要

引言

精液质量下降的确切原因尚不清楚，环境因素被认为起着重要作用。铅（Pb）和镉（Cd）是两种已知的生殖毒物，人类在职业和环境中都会接触到它们，并且会对睾丸功能产生负面影响。本研究的目的是评估特发性少弱精子症男性精浆中的铅和镉水平，并与健康 fertile 对照进行比较，同时将这些水平与传统精液参数、精子低渗肿胀（HOS）百分比、精子 DNA 碎片百分比和精液活性氧（ROS）水平相关联。

材料与方法

本研究纳入了 30 例患有特发性少精和/或弱精症的不育男性患者以及 30 名健康 fertile 男性作为对照组。测量了所有受试者精浆中的铅和镉水平、精液参数、精子 HOS、精子 DNA 碎片百分比和精液 ROS 检测。

结果

与对照组相比，不育男性精浆中的铅和镉水平显著升高。一方面，精浆中的铅和镉水平与某些精液参数尤其是精子前向运动能力和活力（HOS）之间存在显著负相关。重要的是，另一方面，不育男性和对照组中，精浆中的铅和镉水平与精子 DNA 碎片百分比和精液 ROS 水平之间存在显著正相关。

结论

因此，患有特发性男性不育症的男性精液中的铅和镉水平较高，这与精子运动能力和活力百分比的受损相关，更重要的是与较高的精子 DNA 碎片率和精液 ROS 水平相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/3921854/0fe4ddcb1e0f/CEJU-66-00247-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/3921854/23762bd7b76e/CEJU-66-00247-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/3921854/2011f1fb9dc6/CEJU-66-00247-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/3921854/2011f1fb9dc6/CEJU-66-00247-g006.jpg
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