Kostova Irena
Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria.
Mini Rev Med Chem. 2006 Apr;6(4):365-74. doi: 10.2174/138955706776361457.
Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogs. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Among these properties, their antioxidant effects were extensively examined. In this review, plant derived coumarins and their synthetic analogs will be systematically evaluated based on their plant origin, structure-activity relationship and antioxidant efficacy. Owing their diverse effects and inconclusive results from different in vitro studies, the mechanism of their action has not yet been fully understood and the correlation of effects with chemical structure is not conclusive at the moment. It is the objective of this review will be to summarize experimental data for different coumarins used as antioxidant agents, because promising data have been reported for a series of these agents. In addition, their ability to bind metal ions represents an additional means of modulating their pharmacological responses.
香豆素是一类古老的化合物，是天然存在的苯并芘衍生物。已从天然来源，特别是绿色植物中鉴定出许多香豆素。这些天然化合物为进一步设计和合成更具活性的类似物提供了有价值的线索。简单香豆素的药理和生化特性及治疗应用取决于取代模式。近年来，香豆素因其多样的药理特性而引起了广泛关注。在这些特性中，对其抗氧化作用进行了广泛研究。在本综述中，将基于植物来源、构效关系和抗氧化功效对植物来源的香豆素及其合成类似物进行系统评估。由于其多样的作用以及不同体外研究结果的不确定性，其作用机制尚未完全阐明，目前其作用与化学结构的相关性也尚无定论。本综述的目的是总结用作抗氧化剂的不同香豆素的实验数据，因为已报道了一系列这类物质的有前景的数据。此外，它们结合金属离子的能力代表了调节其药理反应的另一种方式。
