Khandy Maria T, Grigorchuk Valeria P, Sofronova Anastasia K, Gorpenchenko Tatiana Y
Laboratory of Cell and Developmental Biology, Federal Scientific Center of East-Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, 159 Stoletiya Street, Vladivostok 690022, Russia.
Department of Medical Biology and Biotechnology, School of Medicine and Life Sciences, Far Eastern Federal University, FEFU Campus, 10 Ajax Bay, Russky Island, Vladivostok 690922, Russia.
Plants (Basel). 2024 Feb 22;13(5):601. doi: 10.3390/plants13050601.
, a valuable endangered medicinal plant, is a source of angular pyranocoumarins used in pharmacology. Due to limited resource availability, other pyranocoumarin sources are needed. In the present research, the chemical composition of a closely related species, , was studied, along with . High-performance liquid chromatography and mass-spectrometric analyses, followed by antibacterial activity studies of root extracts from both species, were performed. and differed significantly in coumarin composition. Pyranocoumarins predominated in , while furanocoumarins predominated in . Osthenol, the precursor of angular pyrano- and furanocoumarins, was detected in both and . Angular forms of coumarins were detected in both species according to the mass-spectrometric behavior of the reference. Thus, cannot be an additional source of pyranocoumarins because their content in the plant is critically low. At the same time, the plant contained large amounts of hydroxycoumarins and furanocoumarins. The extracts exhibited moderate antibacterial activity against five standard strains. The extract additionally suppressed the growth of the Gram-negative bacterium . Thus, both species are promising for further investigation in the field of pharmaceuticals as producers of different coumarins.
[一种珍贵的濒危药用植物名称]是药理学中使用的角型吡喃香豆素的来源。由于资源有限，需要其他吡喃香豆素来源。在本研究中，对一种近缘物种[物种名称]的化学成分以及[相关内容]进行了研究。进行了高效液相色谱和质谱分析，随后对这两个物种的根提取物进行了抗菌活性研究。[两个物种名称]在香豆素组成上有显著差异。吡喃香豆素在[一个物种名称]中占主导地位，而呋喃香豆素在[另一个物种名称]中占主导地位。角型吡喃香豆素和呋喃香豆素的前体奥斯特酚在[两个物种名称]中均有检测到。根据参考物质的质谱行为，在这两个物种中均检测到了角型香豆素。因此，[一个物种名称]不能作为吡喃香豆素的额外来源，因为其在植物中的含量极低。同时，该植物含有大量的羟基香豆素和呋喃香豆素。提取物对五种标准菌株表现出中等抗菌活性。[一个物种名称]的提取物还抑制了革兰氏阴性菌[细菌名称]的生长。因此，这两个[物种名称]作为不同香豆素的生产者，在药物领域有进一步研究的前景。
