Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia 1000, Bulgaria.
Curr Med Chem. 2011;18(25):3929-51. doi: 10.2174/092986711803414395.
Coumarins, a well-known class of naturally occurring compounds, display a remarkable array of biochemical and pharmacological actions, some of which suggest that certain members of this group of compounds may significantly affect the function of various mammalian cellular systems. The development of coumarins as antioxidant agents has attracted much attention in recent years. Coumarins afford an opportunity for the discovery of new antioxidants with truly novel mechanisms of action. This review updates and expands the 2006 review by the same author. The review considers and incorporates the most recently published literature on coumarins as related to their antioxidant properties. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogues. Beyond doubt, a deep understanding of the mechanisms of existing synthetic and natural coumarins will build the basis for the rational design.
香豆素是一类众所周知的天然化合物，具有显著的生化和药理作用，其中一些作用表明该类化合物的某些成员可能会显著影响各种哺乳动物细胞系统的功能。近年来，香豆素作为抗氧化剂的发展引起了广泛关注。香豆素为发现具有真正新颖作用机制的新型抗氧化剂提供了机会。本篇综述更新并扩展了作者在 2006 年发表的综述。该综述考虑并纳入了有关香豆素抗氧化特性的最新文献。许多香豆素已从天然来源，特别是绿色植物中被鉴定出来。这些天然化合物为进一步设计和合成更具活性的类似物提供了有价值的先导化合物。毫无疑问，深入了解现有合成和天然香豆素的作用机制将为合理设计奠定基础。
