Ariza M, Pueyo R, Matarín M del M, Junqué C, Mataró M, Clemente I, Moral P, Poca M A, Garnacho A, Sahuquillo J
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1191-3. doi: 10.1136/jnnp.2005.085167. Epub 2006 Apr 13.
To analyse the influence of apolipoprotein (APOE) epsilon4 status on the cognitive and behavioural functions usually impaired after moderate and severe traumatic brain injury (TBI).
In all, 77 patients with TBI selected from 140 consecutive admissions were genotyped for APOE. Each patient was subjected to neuropsychological and neurobehavioural assessment at least 6 months after injury.
Performance of participants carrying the epsilon4 allele was notably worse on verbal memory (Auditory Verbal Learning Test), motor speed, fine motor coordination, visual scanning, attention and mental flexibility (Grooved Pegboard, Symbol Digit Modalities Test and part B of the Trail Making Test) and showed considerably more neurobehavioural disturbances (Neurobehavioral Rating Scale-Revised) than the group without the epsilon4 allele.
In particular, performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE epsilon4 allele than in those without it. More neurobehavioural disturbances are observed in APOE epsilon4 carriers than in APOE epsilon2 and epsilon3 carriers.
分析载脂蛋白（APOE）ε4状态对中重度创伤性脑损伤（TBI）后通常受损的认知和行为功能的影响。
从140例连续入院患者中选取77例TBI患者进行APOE基因分型。每位患者在受伤至少6个月后接受神经心理学和神经行为评估。
携带ε4等位基因的参与者在言语记忆（听觉言语学习测试）、运动速度、精细运动协调、视觉扫描、注意力和心理灵活性（明尼苏达操作速度测验、符号数字模式测验和连线测验B部分）方面的表现明显较差，并且与没有ε4等位基因的组相比，表现出更多的神经行为障碍（修订版神经行为评定量表）。
特别是，与没有APOE ε4等位基因的患者相比，携带该等位基因的患者在推测与颞叶、额叶和白质完整性相关的神经心理学任务上的表现更差。与APOE ε2和ε3携带者相比，在APOE ε4携带者中观察到更多的神经行为障碍。
