Koh Eun Ha, Lee Nam Yong, Kim Eui Chong, Kim Sunjoo
Department of Laboratory Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Chilamdong, Jinju, Korea.
J Korean Med Sci. 2006 Apr;21(2):193-8. doi: 10.3346/jkms.2006.21.2.193.
The M protein and streptococcus pyrogenic exotoxin (SPE A) are important virulence factors in group A streptococci (GAS) infections. The emm types of GAS strains isolated from patients with sepsis were determined by sequencing the 5' N-terminus of the emm gene, encoding the M protein, and clonality analysis using pulsed-field gel electrophoresis. The presence of speA and production of SPE A were also examined. There were no predominant GAS clones. The emm genotypes were variable, and the most common genotype was emm13 (17.9%). The production prevalence of SPE A was 21.4%. The low mortality rate (7.1%) of GAS sepsis might be attributable to the low incidence of virulent strains such as emm1 (10.7%) and emm3 (7.1%), as well as to low production rate of SPE A.
M蛋白和化脓性链球菌致热外毒素（SPE A）是A组链球菌（GAS）感染中的重要毒力因子。通过对编码M蛋白的emm基因5′N端进行测序以及使用脉冲场凝胶电泳进行克隆分析，确定了从败血症患者中分离出的GAS菌株的emm类型。还检测了speA的存在情况和SPE A的产生情况。没有占主导地位的GAS克隆。emm基因型各不相同，最常见的基因型是emm13（17.9%）。SPE A的产生率为21.4%。GAS败血症的低死亡率（7.1%）可能归因于emm1（10.7%）和emm3（7.1%）等毒力菌株的低发生率以及SPE A的低产生率。
