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通过对与毒力相关基因进行自动DNA测序，对从患有咽炎的墨西哥儿童中分离出的A组链球菌菌株进行特征分析：编码一种补体抑制蛋白的基因存在意外的大量变异。

Characterization of group A Streptococcus strains recovered from Mexican children with pharyngitis by automated DNA sequencing of virulence-related genes: unexpectedly large variation in the gene (sic) encoding a complement-inhibiting protein.

作者信息

Mejia L M, Stockbauer K E, Pan X, Cravioto A, Musser J M

机构信息

Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, D.F.

出版信息

J Clin Microbiol. 1997 Dec;35(12):3220-4. doi: 10.1128/jcm.35.12.3220-3224.1997.

DOI:10.1128/jcm.35.12.3220-3224.1997
PMID:9399523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC230151/
Abstract

Sequence variation was studied in several target genes in 54 strains of group A Streptococcus (GAS) cultured from children with pharyngitis in Mexico City. Although 16 distinct emm alleles were identified, only 4 had not been previously described. Virtually all bacteria (31 of 33 [94%] with the streptococcal pyrogenic exotoxin gene (speA) had emm1-related, emm3, or emm6 alleles. The gene (sic) encoding an extracellular GAS protein that inhibits complement function was unusually variable among isolates with the emm1 family of alleles, with a total of seven variants identified. The data suggest that many GAS strains infecting Mexican children are genetically similar to organisms commonly encountered in the United States and western Europe. Sequence variation in the sic gene is useful for rapid differentiation among GAS isolates with the emm1 family of alleles.

摘要

对从墨西哥城患咽炎儿童中培养出的54株A组链球菌（GAS）的几个靶基因进行了序列变异研究。虽然鉴定出了16个不同的emm等位基因，但只有4个是以前未描述过的。几乎所有细菌（33株中有31株[94%]带有链球菌致热外毒素基因（speA））具有emm1相关、emm3或emm6等位基因。在具有emm1等位基因组的分离株中，编码一种抑制补体功能的细胞外GAS蛋白的基因异常多变，共鉴定出7个变体。数据表明，许多感染墨西哥儿童的GAS菌株在基因上与在美国和西欧常见的菌株相似。sic基因中的序列变异有助于对具有emm1等位基因组的GAS分离株进行快速区分。

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J Infect Dis. 1997 Feb;175(2):392-9. doi: 10.1093/infdis/175.2.392.
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Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains.化脓性链球菌细胞外半胱氨酸蛋白酶的失活显著降低了M3和M49血清型菌株对小鼠的致死率。
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Survey of emm gene sequences and T-antigen types from systemic Streptococcus pyogenes infection isolates collected in San Francisco, California; Atlanta, Georgia; and Connecticut in 1994 and 1995.1994年和1995年在加利福尼亚州旧金山、佐治亚州亚特兰大以及康涅狄格州收集的化脓性链球菌全身性感染分离株的emm基因序列和T抗原类型调查。
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An outbreak of invasive group A streptococcal disease associated with high carriage rates of the invasive clone among school-aged children.一起与学龄儿童中侵袭性克隆高携带率相关的侵袭性A群链球菌病暴发。
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Horizontal gene transfer among group A streptococci: implications for pathogenesis and epidemiology.A组链球菌中的水平基因转移：对发病机制和流行病学的影响。
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Sequencing emm-specific PCR products for routine and accurate typing of group A streptococci.对A群链球菌进行常规准确分型的emm特异性PCR产物测序。
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