Brass Volker, Moradpour Darius, Blum Hubert E
Department of Medicine II, University of Freiburg, D-79106 Freiburg, Germany.
Int J Med Sci. 2006;3(2):29-34. doi: 10.7150/ijms.3.29. Epub 2006 Apr 1.
Fascinating progress in the understanding of the molecular biology of hepatitis C virus (HCV) was achieved recently. The replicon system revolutionized the investigation of HCV RNA replication and facilitated drug discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mechanisms. Most recently, recombinant infectious HCV could be produced in cell culture, rendering all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In this review, we summarize recent advances and discuss future research directions.
最近，在丙型肝炎病毒（HCV）分子生物学的理解方面取得了引人注目的进展。复制子系统彻底改变了对HCV RNA复制的研究，并促进了药物发现。用于HCV糖蛋白功能分析的新系统使HCV受体候选物得以验证，并对细胞进入机制进行了研究。最近，重组感染性HCV可以在细胞培养物中产生，使得病毒生命周期的所有步骤，包括病毒颗粒的进入和释放，都能够进行系统分析。在这篇综述中，我们总结了最近的进展并讨论了未来的研究方向。
