Chung In-Sung, Kim Jon-Ghan, Choi Sang-Kug, Bae Jong-Youn, Lee Mi-Young
Department of Occupational and Environmental Medicine, Dongsan Medical Center.
J Prev Med Public Health. 2006 Mar;39(2):171-6.
The objective of this study is to assess the factors influencing biological monitoring of textile coating factory workers exposed to N,N-dimethylformamide (DMF).
We studied 35 workers who were occupationally exposed to DMF from 9 textile coating factories. The study was carried out in two phases; summer and winter. While air concentration of DMF, temperature and humidity were assessed in order to monitor the atmospheric conditions, biological monitoring was done to determine the internal dose by analyzing the N-methylformamide (NMF) collected from urine at the beginning and end of the shift. Questionnaires and medical surveillance were also obtained during the two phases.
Median air concentrations of DMF in winter and summer were 1.85 ppm and 2.78 ppm respectively. Also the difference between the urinary NMF concentration at the beginning and end of the shift (delta NMF) was always significant in each season (P < 0.001). The correlations between log DMF in air, log end-of-shift urinary NMF (r = 0.555, P < 0.001) and log delta NMF (r = 0.444, P < 0.001) was statistically significant in summer. The temperature, humidity, a shift system and different styles of clothing worn were significantly different during the two phases. In a multivariate analysis, temperature and the concentration of DMF in the air were the main factors influencing biological monitoring of textile coating factory workers.
Concerning more comprehensive prevention measures to reduce exposure for those workers occupationally exposed to DMF, dermal exposure conditions such as temperature and humidity together with the air concentration of DMF should be assessed and biological monitoring is necessary to reduce adverse health effects, especially during the summer.
本研究的目的是评估影响接触N,N - 二甲基甲酰胺（DMF）的纺织涂层厂工人生物监测的因素。
我们研究了来自9家纺织涂层厂的35名职业接触DMF的工人。研究分两个阶段进行；夏季和冬季。在监测大气条件时评估了DMF的空气浓度、温度和湿度，同时通过分析轮班开始和结束时从尿液中收集的N - 甲基甲酰胺（NMF）来进行生物监测以确定内部剂量。在两个阶段还获取了问卷和医学监测数据。
冬季和夏季DMF的空气浓度中位数分别为1.85 ppm和2.78 ppm。而且每个季节轮班开始和结束时尿NMF浓度的差异（ΔNMF）始终具有统计学意义（P < 0.001）。夏季空气中log DMF与轮班结束时尿NMF的log值（r = 0.555，P < 0.001）以及log ΔNMF（r = 0.444，P < 0.001）之间的相关性具有统计学意义。两个阶段的温度、湿度、轮班制度和穿着的不同服装款式存在显著差异。在多变量分析中，温度和空气中DMF的浓度是影响纺织涂层厂工人生物监测的主要因素。
对于那些职业接触DMF的工人，为了采取更全面的预防措施以减少接触，应评估温度和湿度等皮肤接触条件以及DMF的空气浓度，并且进行生物监测对于减少不良健康影响是必要的，尤其是在夏季。
