Paech Michael J, Magann Everett F, Doherty Dorota A, Verity Lisa J, Newnham John P
Department of Anesthesiology, King Edward Memorial Hospital, The University of Western Australia, Perth, Australia.
Am J Obstet Gynecol. 2006 Jun;194(6):1596-602; discussion 1602-3. doi: 10.1016/j.ajog.2006.01.009. Epub 2006 Apr 17.
The purpose of this study was to determine whether magnesium sulfate decreases postoperative pain and analgesic consumption.
Women who underwent elective cesarean delivery were randomized into groups according to high-dose magnesium sulfate (50 mg/kg load and 2 g/h), low-dose magnesium sulfate (25 mg/kg load and 1 g/h), or placebo. Before the delivery, the dose of patient-controlled opioid that was used and the visual analogs of pain during the first 48 hours after delivery and at 6 weeks were assessed.
Forty-two women were assigned randomly to the high-dose arm; 38 women were assigned to the low-dose magnesium arms, and 40 women were assigned to the control arm. The cumulative opioid use (P = .636); pain scores at 6, 12, 24, and 48 hours at rest (P = .786) and with movement (P = .179); the use of analgesics after hospital discharge (P = .711); and wound pain with movement (P = .429) or pressure (P = .144) after 6 weeks were similar.
Magnesium sulfate does not reduce the severity of short-term or long-term (6 weeks) pain after cesarean delivery.
本研究旨在确定硫酸镁是否能减轻术后疼痛并减少镇痛药物的使用量。
将接受择期剖宫产的女性随机分为高剂量硫酸镁组（负荷剂量50mg/kg，维持剂量2g/h）、低剂量硫酸镁组（负荷剂量25mg/kg，维持剂量1g/h）或安慰剂组。在分娩前，评估患者自控阿片类药物的使用剂量以及分娩后48小时内和6周时的视觉模拟疼痛评分。
42名女性被随机分配至高剂量组；38名女性被分配至低剂量硫酸镁组，40名女性被分配至对照组。累积阿片类药物使用量（P = 0.636）；休息时6、12、24和48小时的疼痛评分（P = 0.786）以及活动时的疼痛评分（P = 0.179）；出院后镇痛药物的使用情况（P = 0.711）；以及6周后活动时（P = 0.429）或按压时（P = 0.144）的伤口疼痛情况均相似。
硫酸镁不能减轻剖宫产术后短期或长期（6周）疼痛的严重程度。
