Benhaj Amor Mondher, Barakette Mohamed, Dhahri Sami, Ouezini Rami, Lamine Khaled, Jebali Adel, Ferjani Mustapha
Service d'Anesthśie Réanimation, Hôpital Militaire de Tunis.
Tunis Med. 2008 Jun;86(6):550-5.
Evaluate the effect of intra and postoperative magnesium sulphate infusion on postoperative pain in abdominal surgery.
Prospective double-blind randomized controlled study. Forty eight patients were randomly allocated to receive in the induction of anaesthesia, intraoperatively and six hours postoperatively either magnesium sulphate M Group (bolus 50 mg/kg and 0.5 g/h) or placebo (P Group). Patients were given a dose of morphine (0.1 mg/kg) IV, 45 min before the end of surgery. Sedation, pain scores, cumulative morphine consumption and adverse effects were recorded up to 24 hours postoperatively.
The duration of anaesthesia was similar in both groups. The time of the first demand of morphine was significantly longer in M Group then in P Group, respectively (18+/-5 min vs 7+/-1 min, p=0.03). Morphine consumption was significantly higher in control group than M group on the first postoperative day (52+/-4 mg vs 30+/-3 mg, p=0.0002). Pain scores were significantly lower in M group than in P group. Serum magnesium concentration was significantly higher in the M group. The frequency of side effects was similar in the two groups.
The results of the study support magnesium sulphate as useful adjuvant for postoperative analgesia in abdominal surgery.
评估术中及术后输注硫酸镁对腹部手术术后疼痛的影响。
前瞻性双盲随机对照研究。48例患者在麻醉诱导期、术中及术后6小时被随机分配接受硫酸镁治疗（M组，负荷剂量50mg/kg，维持剂量0.5g/h）或安慰剂治疗（P组）。在手术结束前45分钟，静脉给予患者一剂吗啡（0.1mg/kg）。记录术后24小时内的镇静情况、疼痛评分、吗啡累积用量及不良反应。
两组麻醉持续时间相似。M组首次需要吗啡的时间显著长于P组（分别为18±5分钟和7±1分钟，p = 0.03）。术后第一天对照组吗啡用量显著高于M组（52±4mg对30±3mg，p = 0.0002）。M组疼痛评分显著低于P组。M组血清镁浓度显著更高。两组副作用发生率相似。
该研究结果支持硫酸镁作为腹部手术术后镇痛的有效辅助药物。
