Britton Collette, Murray Linda
Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK.
Int J Parasitol. 2006 May 31;36(6):651-9. doi: 10.1016/j.ijpara.2006.02.010. Epub 2006 Mar 15.
Information on the functional genomics of Caenorhabditis elegans has increased significantly in the last few years with the development of RNA interference. In parasitic nematodes, RNA interference has shown some success in gene knockdown but optimisation of this technique will be required before it can be adopted as a reliable functional genomics tool. Comparative studies in C. elegans remain an appropriate alternative for studying the function and regulation of some parasite genes and will be extremely useful for fully exploiting the increasing parasite genome sequence data becoming available.
在过去几年中，随着RNA干扰技术的发展，秀丽隐杆线虫功能基因组学的相关信息显著增加。在寄生线虫中，RNA干扰在基因敲低方面已取得了一些成功，但在将该技术用作可靠的功能基因组学工具之前，还需要对其进行优化。秀丽隐杆线虫的比较研究仍然是研究某些寄生虫基因功能和调控的合适替代方法，对于充分利用日益增多的可用寄生虫基因组序列数据极为有用。
