Kalman David, Kahler Christopher W, Garvey Arthur J, Monti Peter M
Department of Psychiatry, School of Medicine, Boston University, Boston, MA 02118, USA.
J Subst Abuse Treat. 2006 Apr;30(3):213-7. doi: 10.1016/j.jsat.2006.01.001.
This study reports findings from an investigation of the efficacy of high-dose nicotine patch (NP) therapy for heavy smokers with a history of alcohol dependence. One hundred thirty participants were randomly assigned to 42 or 21 mg of transdermal nicotine. Follow-up assessments were conducted at 4, 12, 24, and 36 weeks. Differences between dose conditions were nonsignificant, although, unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence rates in the 21- and 42-mg NP conditions on Week 36 follow-up were 16.9% and 9.2%, respectively. Patch condition did not interact with severity of nicotine dependence. However, nicotine abstinence at follow-up was related to a longer length of alcohol abstinence. No evidence was found for better outcomes as a function of the percentage of baseline cotinine replaced by NPs. Future research should focus primarily on investigating ways to improve smoking quit rates for smokers in early alcohol recovery.
本研究报告了一项针对有酒精依赖史的重度吸烟者进行高剂量尼古丁贴片（NP）疗法疗效调查的结果。130名参与者被随机分配接受42毫克或21毫克的经皮尼古丁治疗。在第4、12、24和36周进行随访评估。尽管出乎意料的是，结果显示21毫克NP组的参与者情况较好，但剂量条件之间的差异并不显著。在第36周随访时，21毫克和42毫克NP组的尼古丁戒断率分别为16.9%和9.2%。贴片条件与尼古丁依赖的严重程度没有相互作用。然而，随访时的尼古丁戒断与更长时间的酒精戒断有关。没有发现根据NP替代基线可替宁的百分比而有更好结果的证据。未来的研究应主要集中在调查提高早期酒精康复吸烟者戒烟率的方法上。
