Hinrichs Christian S, Gattinoni Luca, Restifo Nicholas P
National Cancer Institute, Surgery Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Opin Immunol. 2006 Jun;18(3):363-70. doi: 10.1016/j.coi.2006.03.009. Epub 2006 Apr 17.
The differentiation state of CD8+ T cells has emerged as a crucial determinant of their ability to respond to tumor and infection. Signals from T-cell receptors, co-stimulatory molecules and cytokine receptors direct the differentiation process. These signals 'program' sustained and heritable gene expression patterns that govern progressive differentiation and lineage commitment. The epigenetic mechanisms by which T cells are programmed are just beginning to be elucidated. Understanding the mechanisms that control CD8+ T-cell differentiation is important in the development of novel immunotherapy strategies.
CD8+ T细胞的分化状态已成为其对肿瘤和感染作出反应能力的关键决定因素。来自T细胞受体、共刺激分子和细胞因子受体的信号引导分化过程。这些信号“编程”了持续且可遗传的基因表达模式，这些模式控制着渐进性分化和谱系定向。T细胞被编程的表观遗传机制才刚刚开始被阐明。了解控制CD8+ T细胞分化的机制对于开发新型免疫治疗策略很重要。
