Carrasco Yolanda R, Batista Facundo D
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom.
Curr Opin Immunol. 2006 Jun;18(3):286-91. doi: 10.1016/j.coi.2006.03.013. Epub 2006 Apr 17.
B cell recognition of membrane-bound antigens leads to the formation of an immunological synapse and efficient B cell activation. Ongoing research has been directed towards identifying the parameters that regulate this process. Furthermore, considerable attention has also been focused on the cell types that mediate presentation of intact antigens to B cells, as well as on the mechanisms that underlie it. Whilst there are still many unanswered questions, recent developments in these areas begin to shed light on an emerging field.
B细胞对膜结合抗原的识别会导致免疫突触的形成和B细胞的有效激活。目前的研究一直致力于确定调节这一过程的参数。此外，相当多的注意力也集中在介导完整抗原呈递给B细胞的细胞类型以及其潜在机制上。虽然仍有许多未解决的问题，但这些领域的最新进展开始为一个新兴领域带来曙光。
