Gianchandani Erwin P, Brautigan David L, Papin Jason A
Department of Biomedical Engineering, University of Virginia, Box 800759, Health System, Charlottesville, VA 22908, USA.
Trends Biochem Sci. 2006 May;31(5):284-91. doi: 10.1016/j.tibs.2006.03.007. Epub 2006 Apr 17.
Metabolic, regulatory and signaling pathways have been characterized in detail over the past century. As the amount of genomic, proteomic and metabolic data has increased, and the mathematical and analytical capabilities of interrogating these data have advanced, the overlapping roles of pathway constituents have been described. These developments reflect the truly integrated nature of subcellular biochemical networks. Systems analyses, including the reconstruction of stoichiometric networks, provide a key set of tools for quantifying overlap among the metabolic, regulatory and signaling functions of network components. Accounting for this integration is crucial for accurately describing the function of biochemical networks.
在过去的一个世纪里，代谢、调节和信号通路已得到详细的表征。随着基因组学、蛋白质组学和代谢数据量的增加，以及分析这些数据的数学和分析能力的提高，已对通路成分的重叠作用进行了描述。这些进展反映了亚细胞生化网络真正的整合性质。系统分析，包括化学计量网络的重建，为量化网络成分的代谢、调节和信号功能之间的重叠提供了一套关键工具。考虑到这种整合对于准确描述生化网络的功能至关重要。
