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Pyridoindole stobadine is a potent scavenger of hydroxyl radicals.

作者信息

Stefek M, Benes L

机构信息

Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

出版信息

FEBS Lett. 1991 Dec 9;294(3):264-6. doi: 10.1016/0014-5793(91)81444-d.

DOI:10.1016/0014-5793(91)81444-d
PMID:1661687
Abstract

Stobadine is a potent scavenger of OH. radicals generated chemically in a free solution with kappa 2 higher than 10(10).M-1.s-1 as determined by two independent methods, namely destruction of deoxyribose and oxidation of 2-keto-4-methiolbutyric acid (KMBA). The high efficacy of stobadine to prevent ethylene production from KMBA was observed also in enzymatic (xanthine-xanthine oxidase-driven Fenton) and membrane-bound (NADPH-dependent microsomal electron transfer) sources of OH. radicals.

摘要

相似文献

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